Nora Eccles Harrison Cardiovascular Research & Training Institute

Timeline Stories

ECG Imaging of electrophysiologically abnormal substrates in infarcted hearts

14 May 2020
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Drs. MacLeod and Taccardi strengthen the validity of using electrocardiographic imaging to detect and localize areas of myocardial infarct and structural disease.
Burnes JE, Taccardi B, MacLeod RS, and Rudy Y. Noninvasive ECG Imaging of electrophysiologically abnormal substrates in infarcted hearts. A model study. Circulation,  101 (5),  533-540, 2000

Human Platelets translate messenger RNAs

14 May 2020
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Drs. Elstad, McIntyre, Prescott, Weyrich, and Zimmerman demonstrate that activated human platelets translate messenger RNAs, which are basally present in an extensive and diverse endogenous transcriptome,  to critical biologically-active proteins, fundamentally altering paradigms in platelet biology. 
Weyrich AS, Dixon DA, Ravinder P, Elstad MR, McIntyre TM, Prescott SM, Zimmerman GA. Signal-dependent translation of a regulatory protein, Bcl-3, in activated human platelets. PNAS, 95: 5556-5561,1998

Three-dimensional electrical activation of the ventricles

14 May 2020
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Drs. Ershler, Lux, and Taccardi demonstrate electrical recordings from the body surface can reliably detect three-dimensional electrical activation of the ventricles.
Oster HS,  Taccardi B, Lux RL, Ershler PR,  Rudy Y. Noninvasive Electrocardiographic Imaging: Reconstruction of Epicardial Potentials, Electrograms, and Isochrones and Localization of Single and Multiple Electrocardiac Events. Circulation,  96 (3), 1012-1024, 1997

Relationship between charge movements associated with ICa and INa-Ca in cardiac myocytes

14 May 2020
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Drs. Bridge and Spitzer show the close connection between calcium influx via calcium current and efflux via sodium-calcium exchange in heart cells.
Bridge JH, Smolley JR, Spitzer KW. The relationship between charge movements associated with ICa and INa-Ca in cardiac myocytes. Science, 248(4953), 376-378, 1990.