Nora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI) delivers cutting-edge cell-to-bedside research and education of cardiovascular disease, which is one of the leading causes of death worldwide. At the CVRTI, we are both developing new insights into the biology of heart muscle cells, and developing novel therapeutics for patients with heart failure and cardiac arrhythmias such as sudden cardiac death.

Located at the University of Utah, the CVRTI nucleates a campus wide, multidisciplinary team of fourteen individual investigator laboratories who are both scientists and physician scientists. The research of the laboratories spans from basic muscle biology and channel electrophysiology to metabolism and genetics. Founded in 1969, the CVRTI is one of the oldest cardiovascular institutes in the country, and its research has already impacted clinical care from development of the first artificial heart, to the genetic basis of long QT arrhythmias, to using electricity to map heart dimensions for arrhythmia ablation, to myocardial recovery.

Cardiovascular Research and
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October Seminar Series

Latest Blog

Heart disease is extremely common in the USA. Over 600,000 people die from heart disease in the United States each year, accounting for 1 in 4 causes of death. Heart disease can progress into heart failure, from which it is difficult for patients to recover normal heart function. Fortunately, thanks to advances in research, there are more treatment options and the number of available pharmacological therapies for treating heart failure, particularly for heart failure...
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Latest Publications

<h3>eLife publication from the Shaw Lab</h3>

eLife publication from the Shaw Lab

After 30 years of worldwide research in ischemic-preconditioning, Shimura et al have identified the mediator molecule. Stress responsive GJA1-20k works with actin to cause a newly identified protective mitochondrial fission, providing a therapeutic option to protect organs against anticipated ischemia.
<h3>Nature Communications publication from the Drakos Lab</h3>

Nature Communications publication from the Drakos Lab

Our findings demonstrate that VDAC2 plays a crucial role in cardiac function by influencing cellular calcium signaling. Through this unique role in cellular calcium dynamics and excitation-contraction coupling VDAC2 emerges as a plausible therapeutic target for heart failure (HF)
<h3>JACC Clinical Electrophysiology publication from the Ranjan Lab</h3>

JACC Clinical Electrophysiology publication from the Ranjan Lab

This data provides mechanistic insights into atrial fibrillation (AF) recurrence, suggesting that post-ablation scar pattern dividing the atria into smaller regions is an important and better predictor than left atrium (LA) volume and total scar, with improved long-term outcomes in persistent AF.


We’re Hiring!
Openings for graduate students, postdoctoral fellows, and grants/contracts officer at the CVRTI.

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