Nora Eccles Harrison Cardiovascular Research & Training Institute

CVRTI Cardiovascular Research Seminar Series

Novel risk stratification approaches in electrophysiology

In this video segment of the CVRTI Seminar Series, invited distinguished speaker, Dr. Sharlene M. Day, MD, discusses : New Therapies for Hypertrophic Cardiomyopathy: Some things old and some things new

Speaker:

Sharlene M. Day, MD, Associate Professor of Medicine and Genetics, Director of Translational Research for Cardiovascular Medicine and Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania

Novel risk stratification approaches in electrophysiology

In this video segment of the CVRTI Seminar Series, invited distinguished speaker, Dr. Benjamin A. Steinberg, MD, discusses : Novel risk stratification approaches in electrophysiology

Speaker:

Benjamin A. Steinberg, MD, MHS, FACC, FHRS, Associate Professor of Medicine, Cardiovascular Medicine Division, University of Utah

Cardio-Oncology: A Novel Platform forCardiovascular Investigation

In this video segment of the CVRTI Seminar Series, invited distinguished speaker, Dr. Javid Moslehi, MD, discusses Cardio-Oncology: A Novel Platform for Cardiovascular Investigation.

Speaker:

Javid Moslehi, MD, William Grossman Distinguished Professor in Cardiology, Section Chief, Cardio-Oncology & Immunology, Associate Professor in Residence, UCSF School of Medicine, Cardiovascular Research Institute (CVRTI), University of California San Francisco

The secret life of the endothelium

In this video segment of the CVRTI Seminar Series, invited distinguished speaker, Dr. Lisa A. Lesniewsk, discusses the secret life of the endothelium.

Speaker:

Lisa A. Lesniewski, MA, PhD, Professor of Internal Medicine, Division of Geriatrics, Adjunct Associate Professor, Department of Nutrition and Integrative Physiology, GRECC Investigator and Co-Principal Investigator of the Translational Vascular Physiology Lab

How to Improve Brain Health in Patients with Atrial Fibrillation

In this video segment of the CVRTI Seminar Series, invited distinguished speaker, Dr. Jared Bunch, discusses improving brain health in patients with atrial fibrillation.

Speaker:

T. Jared Bunch, MD Professor of Medicine Section Chief, Clinical Cardiac Electrophysiology University of Utah

Cardiac Sarcomere Protein Quality Control and BAG3: Repairing the Engine without Stopping the Car

In this video segment of the CVRTI Seminar Series, invited speaker, Dr. Jonathan Kirk, discusses cardiac sarcomere protein quality control and the gene encoding BAG3.

Dr. Kirk discusses the challenges involved with repairing the sarcomere without stopping the heart, analogous to repairing a car engine without stopping the car. His work builds on prior studies from the late 1960s that examine how heart muscle becomes weak in heart failure. Currently, Dr. Kirk explores the role of BAG3 and other associated proteins in the failing heart.

Speaker:
Jonathan A. Kirk, PhD.
Associate Professor
Department of Cell and Molecular Physiology
Loyola University Chicago Stritch School of Medicine

Cardiac MRI for Measuring Myocardial Fibrosis, Perfusionand Oxygenation

In this video segment of the CVRTI Seminar Series, invited speaker, Dr. Edward Dibella, discusses Cardiac MRI imaging for measuring myocardial fibrosis, perfusion and oxygenation.

Dr. Dibella discusses the technical mechanism and physics involved with generating an MRI image and the relevance of imaging in the cardiology clinical setting. The seminar concludes with a discussion on the challenges of obtaining images and future directions for improving MRI imaging to obtain better results in the cardiovascular system.

Speaker:

Edward Dibella, PhD. Professor of Radiology and Imaging Sciences Adjunct Professor of Electrical & Computer Engineering and Biomedical Engineering Director of the Utah Center for Advanced Imaging Research (UCAIR) University of Utah, Salt Lake City, Utah

Myocarditis: From Coxsackies Virus to Cytoskeleton to COVID-19

In this video segment of the CVRTI Seminar Series, invited distinguished speaker, Dr. Kirk Knowlton, presents his current research on myocarditis involving the cytoskeletal elements found in heart muscle cells in response to exposure to viruses such as Coxsackievirus and Coronavirus.

Dr. Knowlton begins the seminar with a look at traditional myocarditis. The Knowlton Lab investigates possible genetic and/or environmental factors which compromise the cell membrane and allow a virus to enter the cell much easier than under normal conditions. Dr. Knowlton concludes with a discussion of COVID-19 effects on the cardiovascular system and possible treatment approaches, including a discussion on monoclonal antibody treatment of COVID-19 as it pertains to the heart.

Speaker:

Kirk U. Knowlton, M.D., FACC, FAHA Intermountain Medical Center Salt Lake City, Utah

Arterial Senescence and Telomere Dysfunction: Implications for Arterial Aging

In this video segment of the CVRTI Seminar Series, invited distinguished University of Utah speaker, Dr. Anthony Donato, describes arterial senescence (cell death) and telomere dysfunction relating to arterial aging.

Dr. Donato’s findings suggest the majority of cardiovascular death is due to arterial disease. His laboratory investigates the capped ends of chromosomes, also known as telomeres, and uses translational research genetic models to explore possible interventions to preserve telomere length and arterial health.

Speaker:

Anthony Donato, PhD. Co-Directory, Translation Vascular Physiology Laboratory Professor, Department of Internal Medicine, University of Utah

Exercise and Plakophilin-2 Deficiency: The Double-Hit of Arrhythmogenic Cardiomyopathy

In this video segment of the CVRTI Seminar Series, invited distinguished speaker, Dr. Mario Delmar, describes the function and role of the gene Plakophilin-2 (PKP2) in Arrhythmogenic Right Ventricular Cardiomyopathy—an inherited heart muscle disease.

Dr. Delmar’s findings suggest that a mutation in the PKP2 gene can cause the muscle cells of the heart to be replaced with fatty tissue causing the normally strong but flexible heart, to be more rigid and weak. This disease may at first be quite subtle with effects such as diminished performance, but can advance to more serious effects including heart failure and sudden cardiac death.

Speaker:

Mario Delmar, MD, PhD Patricia M. and Robert H. Martinsen Professor of Cardiology, Department of Medicine at NYU Grossman School of Medicine Professor, Department of Cell Biology at NYU Grossman School of Medicine New York University

Modeling and Imaging Cardiac Electrical Excitation

In this video segment of the CVRTI Seminar Series, invited distinguished speaker, Dr. Yoram Rudy, presents his current research of modeling and imaging cardiac electrical excitation.

Dr. Rudy’s discussion of his current work follows disease progression starting with ion channels located inside the cells of the heart, where structural changes cause electrical activity of the heart to change. These changes often have a dramatic impact on the larger components causing deleterious effects in larger systems such as cells, tissues, organs and even the entire organism. Dr. Rudy developed Non-Invasive Electrocardiographic Imaging (ECGI) to aid in the detection and treatment of these cardiovascular anomalies.

Speaker:

Yoram Rudy Ph.D., F.A.H.A., F.H.R.S Director, Cardiac Bioelectricity and Arrhythmia Center (CBAC) The Fred Saigh Distinguished Professor of Engineering Professor of Biomedical Engineering, Cell Biology & Physiology, Medicine, Radiology, and Pediatrics Washington University, St. Louis, Missouri