CVRTI Timeline
Maxwell M. Wintrobe, MD, then Chair of the Department of Internal Medicine, serves as the Planning Coordinator of CVRTI and later as the first Director (1969).
The Utah Board of Regents formally establishes the Nora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI) at the University.
Drs. Abildskov, Burgess, Lux, and Vincent study he utility of body surface electrical mapping in detecting ventricular recovery properties in humans. Abildskov JA, Burgess MJ, Lux RL, Wyatt R, Vincent…
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Drs. Abildskov, Burgess, and Lux demonstrate the conditions of increased local disparity of ventricular recovery which increase vulnerability to arrhythmia can be detected by analysis of the body surface electrocardiogram.…
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Dr. William Devries implants the Jarvik-7 heart into Dr. Barney Clark at the University of Utah.
Drs. McIntyre, Prescott, and Zimmerman demonstrate that human endothelial cells rapidly express adhesion molecules for leukocytes when activated by prothrombotic or proinflammatory agonists. Prescott SM, Zimmerman GA, McIntyre TM. Human…
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Drs. McIntyre, Prescott, and Zimmerman demonstrate that thrombin promotes neutrophil-endothelial interaction provided the basis for further research regarding inflammatory cell-cell interactions. Zimmerman GA, McIntyre TM, Prescott SM. Thrombin stimulates the…
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Drs. McIntyre, Prescott, Stafforini, and Zimmerman first demonstrate that the plasma lipid environment significantly modulates PAF hydrolase activity provided the basis for further research concerning lipid signaling and inflammatory regulation.…
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Drs. Bridge and Spitzer show the close connection between calcium influx via calcium current and efflux via sodium-calcium exchange in heart cells. Bridge JH, Smolley JR, Spitzer KW. The relationship…
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Taccardi and Lux publish a structural model of epicardial mapping from the body surface.
Drs. Ershler, Lux, and Taccardi demonstrate electrical recordings from the body surface can reliably detect three-dimensional electrical activation of the ventricles. Oster HS, Taccardi B, Lux RL, Ershler PR, Rudy…
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Drs. Elstad, McIntyre, Prescott, Weyrich, and Zimmerman demonstrate that activated human platelets translate messenger RNAs, which are basally present in an extensive and diverse endogenous transcriptome, to critical biologically-active proteins,…
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Rob MacLeod, PhD, Kenneth Spitzer, PhD, and Bruno Taccardi, MD, PhD are appointed co-Directors.
Drs. MacLeod and Taccardi strengthen the validity of using electrocardiographic imaging to detect and localize areas of myocardial infarct and structural disease. Burnes JE, Taccardi B, MacLeod RS, and Rudy…
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Dr. Tristani identifies several novel potassium channel mutations that provide new insight concerning the mechanism of cardiac arrhythmia in patients with Anderson syndrome. Tristani-Firouzi M, Jensen JL, Donaldson MR, Sansone…
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Dr. Sheets defines the molecular basis of lidocaine’s effect on sodium channel gating. Sheets MF and Hanck DA. Molecular action of lidocaine on the voltage sensors of sodium channels. J.…
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The first comprehensive evaluation of selective actions of intracellular and extracellular pH on calcium handling in heart cells by Dr. Spitzer. Saegusa, N., Moorhouse, E., Vaughan-Jones, R.D., Spitzer KW. Influence…
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Dr. Sanguinetti describes the molecular basis of gating in a key potassium channel involved in cardiac action potential repolarization. Wu W, Gardner A, Sanguinetti MC. Cooperative Subunit Interactions Mediate Fast…
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Drs. Drakos, Sachse, Selzman, and Tristani-Firouzi demonstrate that end-stage human heart failure induces development of sheet-like invaginations of the cell membrane that may constitute a precondition and predictor for functional…
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Drs. Dosdall, MacLeod, and Ranjan demonstrate late gadolinium enhancement-MRI done acutely after myocardial ablation can quantify edema in the tissue and correlate the acute MRI findings with chronic lesion formation.…
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Drs. Franklin, Warren, and Zaitsev demonstrate mitochondrial metabolism can be regulated by Smyd1, an important modulator of gene expression in the heart. Warren J, Tracy CM, Miller MR, Makaju A,…
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Drs. Chaudhuri, Drakos, and Selzman demonstrate heart failure patients who successfully respond to mechanical unloading have major alterations in cardiac metabolism that may facilitate their recovery. Badolia R, Ramadurai DKA,…
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