RESEARCH PUBLICATIONS OF 2023

• Bloom SI, Islam MT, Lesniewski LA, Donato AJ. Mechanisms and consequences of endothelial cell senescence . Nat Rev Cardiol. 2023 Jan
• Drakos SG, Badolia R, Makaju A, Kyriakopoulos CP, Wever-Pinzon O, Tracy CM, Bakhtina A, Bia R, Parnell T, Taleb I, Ramadurai DKA, Navankasattusas S, Dranow E, Hanff TC, Tseliou E, Shankar TS, Visker J, Hamouche R, Stauder EL, Caine WT, Alharethi R, Selzman CH, Franklin S. Distinct Transcriptomic and Proteomic Profile Specifies Patients Who Have Heart Failure With Potential of Myocardial Recovery on Mechanical Unloading and Circulatory Support. Circulation. 2023 Jan
• Kamali R, Kwan E, Regouski M, Bunch TJ, Dosdall DJ, Hsu E, Macleod RS, Polejaeva I, Ranjan R. Contribution of atrial myofiber architecture to atrial fibrillation. PLoS One. 2023 Jan
• Kelly C, Stoecklein HH, Brant-Zawadzki G, Hoareau G, Daley J, Selzman C, Youngquist S, Johnson A. TEE guided REBOA deflation following ROSC for non-traumatic cardiac arrest . Am J Emerg Med. 2023 Jan
• Kogelschatz B, Zenger B, Steinberg BA, Ranjan R, Jared Bunch T. Atrial fibrillation and the risk of early-onset dementia and cognitive decline: An updated review . Trends Cardiovasc Med. 2023 Jan
• Narayan A, Liu Z, Bergquist JA, Charlebois C, Rampersad S, Rupp L, Brooks D, White D, Tate J, MacLeod RS. UncertainSCI: Uncertainty quantification for computational models in biomedicine and bioengineering . Comput Biol Med. 2023 Jan
• Nectoux A, Hoareau, GL. Monitoring Tissue Perfusion: Clinicopathologic Aids and Advanced Techniques . Adv Mon and Proced for Small An Em and Crit Care: Second Edition. 2023 Jan
• Zenger B, Bergquist JA, Busatto A, Good WW, Rupp LC, Sharma V, MacLeod RS. Tipping the scales of understanding: An engineering approach to design and implement whole-body cardiac electrophysiology experimental models . Front Physiol. 2023 Jan
• Zenger B, Rizzi S, Steinberg BA, Ranjan R, Bunch TJ. This is Your Brain, and This is Your Brain on Atrial Fibrillation: The Roles of Cardiac Malperfusion Events and Vascular Dysfunction in Cognitive Impairment . Arrhythm Electrophysiol Rev. 2023 Jan
• Alexander MD, Hoareau G, Zabriskie MS, Palatinus H, Chakravarthula NR, Wang C, Johnson MA. Real-Time Monitoring and Modulation of Blood Pressure in a Rabbit Model of Ischemic Stroke. J Vis Exp. 2023 Feb
• Browne A, Gaines H, Alharethi R, Goodwin M, Selzman CH, Fang JC, Drakos SG, Stehlik J, Hanff TC. Interrupted Time Series Analysis of Donor Heart Use Before and After the 2018 UNOS Heart Allocation Policy Change. J Card Fail. 2023 Feb
• Islam MT, Tuday E, Allen S, Kim J, Trott DW, Holland WL, Donato AJ, Lesniewski LA. Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age . Aging Cell. 2023 Feb
• Jiang X, Toloubidokhti M, Bergquist J, Zenger B, Good WW, MacLeod RS, Wang L. Improving Generalization by Learning Geometry-Dependent and Physics-Based Reconstruction of Image Sequences . IEEE Trans Med Imaging. 2023 Feb
• Johnson JM, Peterlin AD, Balderas E, Sustarsic EG, Maschek JA, Lang MJ, Jara-Ramos A, Panic V, Morgan JT, Villanueva CJ, Sanchez A, Rutter J, Lodhi IJ, Cox JE, Fisher-Wellman KH, Chaudhuri D, Gerhart-Hines Z, Funai K. Mitochondrial phosphatidylethanolamine modulates UCP1 to promote brown adipose thermogenesis.  Sci Adv. 2023 Feb
• Kamali R, Gillete K, Tate J, Abhyankar DA, Dosdall DJ, Plank G, Bunch TJ, Macleod RS, Ranjan R. Treatment Planning for Atrial Fibrillation Using Patient-Specific Models Showing the Importance of Fibrillatory-Areas. Ann Biomed Eng. 2023 Feb
• Balderas E, Sommakia S, Eberhardt D, Lee S, Chaudhuri D. The structural era of the mitochondrial calcium uniporter. Calcium Signals, IOP Publishing. 2023 Mar
• Delisle BP, Aromolaran AS. New Insights into Cardiac Ion Channel Regulation 2.0. Int J Mol Sci. 2023 Mar
• Feuerborn ML, Dechand J, Vadlamudi RS, Torre M, Freedman RA, Groh C, Navaravong L, Ranjan R, Varela D, Bunch TJ, Steinberg BA. Protocol Development and Initial Experience With Intravenous Sotalol Loading for Atrial Arrhythmias . Crit Pathw Cardiol. 2023 Mar
• Hanff TC, Browne A, Dickey J, Gaines H, Harhay MO, Goodwin M, Selzman CH, Fang JC, Drakos SG, Stehlik J. Heart waitlist survival in adults with an intra-aortic balloon pump relative to other Status 2, Status 1, and inotrope Status 3 patients . J Heart Lung Transplant. 2023 Mar
• Lim J, Machin DR, Donato AJ. The role of hyaluronan in endothelial glycocalyx and potential preventative lifestyle strategy with advancing age. Curr Top Membr. 2023 Mar
• Palatinus JA, Valdez S, Taylor L, Whisenant C, Selzman CH, Drakos SG, Ranjan R, Hong T, Saffitz JE, Shaw RM. GJA1-20k Rescues Cx43 Localization and Arrhythmias in Arrhythmogenic Cardiomyopathy. Circ Res. 2023 Mar
• Patel N, Johnson MA, Vapniarsky N, Van Brocklin MW, Williams TK, Youngquist ST, Ford R, Ewer N, Neff LP, Hoareau GL. Elamipretide mitigates ischemia-reperfusion injury in a swine model of hemorrhagic shoc] . Sci Rep. 2023 Mar
• Sessions AJ, May HT, Crandall BG, Day JD, Cutler MJ, Groh CA, Navaravong L, Ranjan R, Steinberg BA, J Bunch T. Increasing time between first diagnosis of atrial fibrillation and catheter ablation adversely affects long-term outcomes in patients with and without structural heart disease . J Cardiovasc Electrophysiol. 2023 Mar
• Szulik MW, Reyes-Múgica M, Marker DF, Gomez AM, Zinn MD, Walsh LK, Ochoa JP, Franklin S, Ghaloul-Gonzalez L. Identification of Two Homozygous Variants in MYBPC3 and SMYD1 Genes Associated with Severe Infantile Cardiomyopathy . Genes. 2023 Mar
• Amrute JM, Lai L, Ma P, Koenig AL, Kamimoto K, Bredemeyer A, Shankar TS, Kuppe C, Kadyrov FF, Schulte LJ, Stoutenburg D, Kopecky BJ, Navankasattusas S, Visker J, Morris SA, Kramann R, Leuschner F, Mann DL, Drakos SG, Lavine KJ. Defining cardiac functional recovery in end-stage heart failure at single-cell resolution . Nat Cardiovasc Res. 2023 Apr
• Chrysakis N, Xanthopoulos A, Magouliotis D, Starling RC, Drakos SG, Triposkiadis F, Skoularigis J. Myocardial Recovery . Diagnostics. 2023 Apr
• Lewis MJ, Hsieh A, Qiao L, Tan R, Kazzi B, Channing A, Griffin EL, Jobanputra V, Su J, Shahryar C, Kochilas L, Gaynor JW, Lee T, Goldmuntz E, Russell M, Mital S, Tristani M, Brueckner M, Newburger J, Shen Y, Chung WK. Association of Predicted Damaging De Novo Variants on Ventricular Function in Individuals With Congenital Heart Disease . Circ Genom Precis Med. 2023 Apr
• Sable C, Li JS, Tristani-Firouzi M, Fagerlin A, Silver RM, Yandel M, Yost HJ, Beaton A, Dale J, Engel M, Watkins D, Spurney C, Skinner AC, Armstrong SC, Shah SH, Allen N, Davis M, Hou L, Van Horn L, Labarthe D, Lloyd-Jones D, Marino B. American Heart Association’s Children’s Strategically Focused Research Network Experience . J Am Heart Assoc. 2023 Apr
• Tokavanich N, Prasitlumkum N, Kewcharoen J, Chokesuwattanaskul R, Phannajit J, Cheungpasitporn W, Akoum N, Ranjan R, Bunch TJ, Navaravong L. Network meta-analysis and systematic review comparing efficacy and safety between very high power short duration, high power short duration, and conventional radiofrequency ablation of atrial fibrillation . J Cardiovasc Electrophysiol. 2023 Apr
• Bear LR, Bergquist JA, Abell E, Cochet H, MacLeod RS, Dubois R, Serinagaoglu Y. Investigation into the importance of using natural PVCs and pathological models for potential-based ECGI validation.  Front Physiol. 2023 May
• Gatsiou A, Tual-Chalot S, Napoli M, Ortega-Gomez A, Regen T, Badolia R, Cesarini V, Garcia-Gonzalez C, Chevre R, Ciliberti G, Silvestre-Roig C, Martini M, Hoffmann J, Hamouche R, Visker JR, Diakos N, Wietelmann A, Silvestris DA, Georgiopoulos G, Moshfegh A, Schneider A, Chen W, Guenther S, Backs J, Kwak S, Selzman CH, Stamatelopoulos K, Rose-John S, Trautwein C, Spyridopoulos I, Braun T, Waisman A, Gallo A, Drakos SG, Dimmeler S, Sperandio M, Soehnlein O, Stellos K. The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammation . Immunity. 2023 May
• Gogulamudi VR, Islam MT, Durrant JR, Adeyemo AO, Trott DW, Hyuhn MH, Zhu W, Donato AJ, Walker AE, Lesniewski LA. Heterozygosity for ADP-ribosylation factor 6 suppresses the burden and severity of atherosclerosis.  PLoS One. 2023 May
• Hirahara AM, Khan MS, Gharbia OA, Lange M, Ishidoya Y, Smego D, Ranjan R, Stoddard GJ, Selzman CH, Dosdall DJ. Antitachycardia pacing at the His bundle is safer than conventional right ventricular antitachycardia pacing in a canine myocardial ischemic injury model.  J Cardiovasc Electrophysiol. 2023 May
• Hogen T, Li J, Balmaceda P, Ha T, Brown GW, Shaw RM, Hong T. Echocardiography Recording in Awake Miniature Pigs.  J Vis Exp. 2023 May
• Huang Q, Tian Y, Mendes J, Ranjan R, Adluru G, DiBella E. Quantitative myocardial perfusion with a hybrid 2D simultaneous multi-slice sequence . Magn Reson Imaging. 2023 May
• Szulik MW, Valdez S, Walsh M, Davis K, Bia R, Horiuchi E, O’Very S, Laxman AK, Sandaklie-Nicolova L, Eberhardt DR, Durrant JR, Sheikh H, Hickenlooper S, Creed M, Brady C, Miller M, Wang L, Garcia-Llana J, Tracy C, Drakos SG, Funai K, Chaudhuri D, Boudina S, Franklin S. SMYD1a protects the heart from ischemic injury by regulating OPA1-mediated cristae remodeling and supercomplex formation.  Basic Res Cardiol. 2023 May
• Bonios MJ, Armenis I, Kogerakis N, Thodou A, Fragoulis S, Georgiadou P, Leontiadis E, Chamogeorgakis T, Drakos SG, Adamopoulos S. Prospective Phenotyping of Right Ventricle Function Following Intra-Aortic Balloon Pump Counterpulsation in Left Ventricular Assist Device Candidates: Outcomes and Predictors of Response.  ASAIO J. 2023 Jun
• Jang MY, Patel PN, Pereira AC, Willcox JAL, Haghighi A, Tai AC, Ito K, Morton SU, Gorham JM, McKean DM, DePalma SR, Bernstein D, Brueckner M, Chung WK, Giardini A, Goldmuntz E, Kaltman JR, Kim R, Newburger JW, Shen Y, Srivastava D, Tristani-Firouzi M, Gelb BD, Porter GA Jr, Seidman CE, Seidman JG. Contribution of Previously Unrecognized RNA Splice-Altering Variants to Congenital Heart Disease . Circ Genom Precis Med. 2023 Jun
• Khan MS, Smego D, Ishidoya Y, Hirahara AM, Offei E, Ruiz Castillo MS, Gharbia O, Li H, Palatinus JA, Krueger L, Hong T, Hoareau GL, Ranjan R, Selzman CH, Shaw RM, Dosdall DJ. A canine model of chronic ischemic heart failure. Am J Physiol Heart Circ Physiol. 2023 Jun
• Thohan V, Abraham J, Burdorf A, Sulemanjee N, Jaski B, Guglin M, Pagani FD, Vidula H, Majure DT, Napier R, Heywood TJ, Cogswell R, Dirckx N, Farrar DJ, Drakos SG; INTELLECT 2-HF Investigators. Use of a Pulmonary Artery Pressure Sensor to Manage Patients With Left Ventricular Assist Devices[T40] . Circ Heart Fail. 2023 Jun
• Yu M, Aguirre M, Jia M, Gjoni K, Cordova-Palomera A, Munger C, Amgalan D, Rosa Ma X, Pereira A, Tcheandjieu C, Seidman C, Seidman J, Tristani-Firouzi M, Chung W, Goldmuntz E, Srivastava D, Loos RJF, Chami N, Cordell H, Dreßen M, Mueller-Myhsok B, Lahm H, Krane M, Pollard KS, Engreitz JM, Gagliano Taliun SA, Gelb BD, Priest JR. Oligogenic Architecture of Rare Noncoding Variants Distinguishes 4 Congenital Heart Disease Phenotypes . Circ Genom Precis Med. 2023 Jun
• Frech TM, Maguire C, Petrey AC, Stoddard GJ, Donato AJ. A systemic sclerosis disease model: can inducible pluripotent stem cells fill an unmet need in defining vascular leak?  Rheumatology. 2023 Jul
• Kyriakopoulos CP, Horne BD, Sideris K, Taleb I, Griffin RJ, Sheffield E, Alharethi R, Hanff TC, Stehlik J, Selzman CH, Drakos SG. Left ventricular functional improvement appears to contribute to lower rates of device thrombosis in patients on durable mechanical circulatory support . J Heart Lung Transplant. 2023 Jul
• Balderas E, Chaudhuri D. Absence (of the uniporter) makes the heart grow fonder: The cardiac response to injury adapts after prolonged EMRE inhibition . J Mol Cell Cardiol. 2023 Aug
• Bloom SI, Liu Y, Tucker JR, Islam MT, Machin DR, Abdeahad H, Thomas TG, Bramwell RC, Lesniewski LA, Donato AJ. Endothelial cell telomere dysfunction induces senescence and results in vascular and metabolic impairments.  Aging Cell. 2023 Aug
• Glotzbach JP, Hanson HA, Tonna JE, Horns JJ, McCarty Allen C, Presson AP, Griffin CL, Zak M, Sharma V, Tristani-Firouzi M, Selzman CH. Familial Associations of Prevalence and Cause-Specific Mortality for Thoracic Aortic Disease and Bicuspid Aortic Valve in a Large-Population Database . Circulation. 2023 Aug
• Hilgart DR, Iversen MM, Peters AY, Zabriskie MS, Hoareau GL, Vapniarsky N, Clark GA, Shah LM, Rieke V. Non-invasive central nervous system assessment of a porcine model of neuropathic pain demonstrates increased latency of somatosensory-evoked potentials . J Neurosci Methods. 2023 Aug
• Lee SH, Duron HE, Chaudhuri D. Beyond the TCA cycle: new insights into mitochondrial calcium regulation of oxidative phosphorylation . Biochem Soc Trans. 2023 Aug
• Machin DR, Trott DW, Gogulamudi VR, Islam MT, Bloom SI, Vink H, Lesniewski LA, Donato AJ. Glycocalyx-targeted therapy ameliorates age-related arterial dysfunction . Geroscience. 2023 Aug
• Matthews E, Palace J, Ramdas S, Sansone V, Tristani-Firouzi M, Vicart S, Willis T. Care Recommendations for the Investigation and Management of Children With Skeletal Muscle Channelopathies . Pediatr Neurol. 2023 Aug
• Pfeuffer AM, Küpfer LK, Shankar TS, Drakos SG, Volk T, Seidel T. Ryanodine Receptor Staining Identifies Viable Cardiomyocytes in Human and Rabbit Cardiac Tissue Slices . Int J Mol Sci. 2023 Aug
• Zimmerman RM, Hernandez EJ, Watkins WS, Blue N, Tristani-Firouzi M, Yandell M, Steinberg BA. An Explainable Artificial Intelligence Approach for Discovering Social Determinants of Health and Risk Interactions for Stroke in Patients With Atrial Fibrillation . Am J Cardiol. 2023 Aug
• Li J, Richmond B, Cluntun AA, Bia R, Walsh MA, Shaw K, Symons JD, Franklin S, Rutter J, Funai K, Shaw RM, Hong T. Cardiac gene therapy treats diabetic cardiomyopathy and lowers blood glucose . JCI Insight. 2023 Sep
• Miller TA, Hernandez EJ, Gaynor JW, Russell MW, Newburger JW, Chung W, Goldmuntz E, Cnota JF, Zyblewski SC, Mahle WT, Zak V, Ravishankar C, Kaltman JR, McCrindle BW, Clarke S, Votava-Smith JK, Graham EM, Seed M, Rudd N, Bernstein D, Lee TM, Yandell M, Tristani-Firouzi M. Genetic and clinical variables act synergistically to impact neurodevelopmental outcomes in children with single ventricle heart disease . Commun Med. 2023 Sep
• Bergquist JA, Zenger B, Rupp LC, Busatto A, Tate J, Brooks DH, Narayan A, MacLeod RS. Uncertainty quantification of the effect of cardiac position variability in the inverse problem of electrocardiographic imaging . Physiol Meas. 2023 Oct
• Bloom SI, Tucker JR, Machin DR, Abdeahad H, Adeyemo AO, Thomas TG, Bramwell RC, Lesniewski LA, Donato AJ. Reduction of double-strand DNA break repair exacerbates vascular aging . Aging. 2023 Oct
• Haugland H, Gamberini L, Hoareau GL, Haenggi M, Greif R, Brede JR; REBOA OHCA expert panel and other Collaborators. Resuscitative endovascular balloon occlusion of the aorta in out-of-hospital cardiac arrest – A Delphi consensus study for uniform data collection . Resusc Plus. 2023 Oct
• Hunt B, Kwan E, Tasdizen T, Bergquist J, Lange M, Orkild B, MacLeod RS, Dosdall DJ, Ranjan R. Transfer Learning for Improved Classification of Drivers in Atrial Fibrillation.  Comput Cardiol. 2023 Oct
• Paccione EN, Lange M, Orkild BA, Bergquist JA, Kwan E, Hunt B, Dosdall D, Macleod RS, Ranjan R. Effects of Biventricular Pacing Locations on Anti-Tachycardia Pacing Success in a Patient-Specific Model . Comput Cardiol. 2023 Oct
• Tedford RJ, Leacche M, Lorts A, Drakos SG, Pagani FD, Cowger J. Durable Mechanical Circulatory Support: JACC Scientific Statement . J Am Coll Cardiol. 2023 Oct
• Machin DR, Sabouri M, Zheng X, Donato AJ. Therapeutic strategies targeting the endothelial glycocalyx. [TH61] Curr Opin Clin Nutr Metab Care. 2023 Nov
• Hammond ME, Zollinger C, Vidic A, Snow GL, Stehlik J, Alharethi RA, Kfoury AG, Drakos S, Hammond MEH. Donor Age, Sex, and Cause of Death and Their Relationship to Heart Transplant Recipient Cardiac Death. J Clin Med. 2023 Dec
• Krulewitz N, Levin NM, Youngquist S, Kelly C, Hoareau G, Johnson MA, Ockerse P. Evaluation of esophageal injuries after defibrillation with transesophageal ultrasound probe in the mid-esophagus in pigs. Am J Emerg Med. 2023 Dec
• Sun B, Rouzbehani OMT, Kramer RJ, Ghosh R, Perelli RM, Atkins S, Fatahian AN, Davis K, Szulik MW, Goodman MA, Hathaway MA, Chi E, Word TA, Tunuguntla H, Denfield SW, Wehrens XHT, Whitehead KJ, Abdelnasser HY, Warren JS, Wu M, Franklin S, Boudina S, Landstrom AP. Nonsense Variant PRDM16-Q187X Causes Impaired Myocardial Development and TGF-β Signaling Resulting in Noncompaction Cardiomyopathy in Humans and Mice . Circ Heart Fail. 2023 Dec