Nora Eccles Harrison Cardiovascular Research & Training Institute

Human Platelets translate messenger RNAs

Drs. Elstad, McIntyre, Prescott, Weyrich, and Zimmerman demonstrate that activated human platelets translate messenger RNAs, which are basally present in an extensive and diverse endogenous transcriptome,  to critical biologically-active proteins, fundamentally altering paradigms in platelet biology. 
Weyrich AS, Dixon DA, Ravinder P, Elstad MR, McIntyre TM, Prescott SM, Zimmerman GA. Signal-dependent translation of a regulatory protein, Bcl-3, in activated human platelets. PNAS, 95: 5556-5561,1998