Nora Eccles Harrison Cardiovascular Research & Training Institute

Timeline Stories

The Role of Non-Glycolytic Glucose Metabolism in Myocardial Recovery

14 May 2020
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Drs. Chaudhuri, Drakos, and Selzman demonstrate heart failure patients who successfully respond to mechanical unloading have major alterations in cardiac metabolism that may facilitate their recovery.
Badolia R, Ramadurai DKA, Abel ED, Ferrin P, Taleb I, Shankar TS, Thodou Krokidi A, Navankasattusas S, McKellar SH, Yin M, Kfoury AG, Wever-Pinzon O, Fang JC, Selzman CH, Chaudhuri D, Rutter J, Drakos SG. The Role of Non-Glycolytic Glucose Metabolism in Myocardial Recovery upon Mechanical Unloading and Circulatory Support in Chronic Heart Failure. Circulation. doi: 10.1161/CIRCULATIONAHA.119.044452, April 2020

Mitochondrial metabolism can be regulated by Smyd1

14 May 2020
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Drs. Franklin, Warren, and Zaitsev demonstrate mitochondrial metabolism can be regulated by Smyd1, an important modulator of gene expression in the heart.
Warren J, Tracy CM, Miller MR, Makaju A, Szulik MW, Yuzyuk TN, Barton DW, Wang L, García J, Sabry AD, Cawley K, Cox J, Yong Hwan Han, Boudina S, Fiehn O, Tucker H, Zaitsev AV, Franklin S. Histone Methyltransferase Smyd1 Regulates Mitochondrial Energetics in the Heart. PNAS,115 (33): E7871-E7880, 2018.

End-stage human heart failure induces development of sheet-like invaginations of the cell membrane

14 May 2020
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Drs. Drakos, Sachse, Selzman, and Tristani-Firouzi demonstrate that end-stage human heart failure induces development of sheet-like invaginations of the cell membrane that may constitute a precondition and predictor for functional cardiac recovery after mechanical unloading.
T. Seidel, S. Navankasattusas, A. Ahmad, N. A. Diakos, W. D. Xu, M. Tristani-Firouzi, M. J. Bonios, I. Taleb, D. Y. Li, C. H. Selzman, S. G. Drakos, and F. B. Sachse. Sheet-like remodeling of the transverse tubular system in human heart failure impairs excitation-contraction coupling and functional recovery by mechanical unloading. Circ, 135(17):1632-45, 2017.

Predicting Edema and Chronic Lesion Size

14 May 2020
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Drs. Dosdall, MacLeod, and Ranjan demonstrate late gadolinium enhancement-MRI done acutely after myocardial ablation can quantify edema in the tissue and correlate the acute MRI findings with chronic lesion formation.
Ghafoori E, Kholmovski EG, Thomas S, Silvernagel J, Angel N, Hu N, Dosdall D, MacLeod R, Ranjan R. Characterization of Gadolinium Contrast-Enhancement of Radiofrequency Ablation Lesions in Predicting Edema and Chronic Lesion Size. Circ Arrhythm Electrophysiol. 10(11), 2017.