Nora Eccles Harrison Cardiovascular Research & Training Institute

The Hoareau Laboratory

The Hoareau Lab Cardiovascular Research Team at CVRTI Fall BBQ
Black and White Heart Research Graphic

The Hoareau laboratory focuses on acute care translational research. Specifically, we study novel therapeutic approaches to mitigate ischemia-reperfusion injury in hemorrhagic shock. We work toward preserving mitochondrial function, the essential cell machinery for energy production. We seek to accelerate the transition of new therapies to clinical practice

Featured Publications

Fluids are a vital tool in the armament of acute care clinicians in both civilian and military resuscitation. We now better understand complications from inappropriate resuscitation with currently available fluids; however, fluid resuscitation undeniably remains a life-saving intervention. Military research has driven the most significant advances in the field of fluid resuscitation and is currently leading the search for the fluids of the future.

Edwards, TH, Hoareau, GL (2020). Fluids of the Future. Front Vet Sci, 7:623227.


Esmolol reduces myocardial injury induced by resuscitative endovascular balloon occlusion of the aorta (REBOA) in a porcine model of hemorrhagic shock

https://pubmed.ncbi.nlm.nih.gov/32669205/

In our porcine model of hemorrhagic shock, zone 1 REBOA was associated with myocardial injury. Pharmacologic heart rate titration with esmolol during occlusion may mitigate the deleterious effects of REBOA on the heart.

Hoareau, GL, Beyer, CA, Caples, CM, Spruce, MW, Gilbert, Z, Grayson, JK, Neff, LP, Williams, TK, Johnson, MA (2020). Esmolol reduces myocardial injury induced by resuscitative endovascular balloon occlusion of the aorta (REBOA) in a porcine model of hemorrhagic shock. Injury, 51, 10:2165-2171.

Not ready for prime time: Intermittent versus partial resuscitative endovascular balloon occlusion of the aorta for prolonged hemorrhage control in a highly lethal porcine injury model

https://pubmed.ncbi.nlm.nih.gov/31996655/

Compared with iREBOA, pREBOA reduced the time spent at full occlusion and the number of precipitous drops in proximal mean arterial pressure while delivering more distal aortic flow but not increasing total blood loss in this highly lethal injury model. Neither technique demonstrated a survival benefit. Further refinement of these techniques is necessary before clinical guidelines are issued.

Johnson, MA, Hoareau, GL, Beyer, CA, Caples, CA, Spruce, M, Grayson, JK, Neff, LP, Williams, TK (2020). Not ready for prime time: Intermittent versus partial resuscitative endovascular balloon occlusion of the aorta for prolonged hemorrhage control in a highly lethal porcine injury model. J Trauma Acute Care Surg, 88, 2:298-304.

The Hoareau Lab Research Team

Guillaume L. Hoareau, PhD, DVM
Assistant Professor

Amy Taylor
Sr. Laboratory Specialist