The Dosdall Laboratory
The Dosdall lab uses a combination of mapping techniques to understand the tissue level substrate remodeling that occurs in conditions such as chronic atrial fibrillation, heart failure, and myocardial infarct that lead to dangerous atrial and ventricular arrhythmias. In combination with our clinical collaborators, we develop translational approaches to diagnose and treat these conditions.
His bundle pacing shows similar ventricular electrical activation as sinus: selective and nonselective His pacing indistinguishable
Our high-density epicardial and endocardial electrical mapping study demonstrated that selective pacing and nonselective His bundle pacing are more electrically similar to sinus rhythm compared with right ventricular and biventricular cardiac resynchronization therapy pacing. Small differences between selective and nonselective His bundle pacing, specifically a wider QRS in nonselective His pacing, do not translate into significant differences in the global activation pattern.
Hirahara, AM, Lange, M, Shah, A, Khan, MS, Ranjan, R, Stoddard, G, Dosdall, DJ (2021). His bundle pacing shows similar ventricular electrical activation as sinus: selective and nonselective His pacing indistinguishable.
Diverse Fibrosis Architecture and Premature Stimulation Facilitate Initiation of Reentrant Activity Following Chronic Atrial Fibrillation
Atrial fibrillation induced atrial remodeling leads to increased obstructive fibrosis and conduction velocity slowing transverse to fiber orientation following premature stimuli. The decrease in conduction velocity causes a decrease in the cardiac wavelength, and increases the likelihood of reentry and atrial fibrillation onset.
Angel, N, Li, LI, Macleod, RS, Marrouche, N, Ranjan, R, Dosdall, DJ (2015). Diverse Fibrosis Architecture and Premature Stimulation Facilitate Initiation of Reentrant Activity Following Chronic Atrial Fibrillation. J Cardiovasc Electrophysiol, 26, 12:1352-60.
Endocardial Activation Drives Activation Patterns During Long-Duration Ventricular Fibrillation and Defibrillation
Sudden cardiac arrest because of ventricular fibrillation is a leading cause of death. Organized patterns in prolonged ventricular fibrillation are driven by activity on the endocardium. Failed defibrillation shocks in prolonged but not short-duration ventricular fibrillation alter endocardial fibrillation patterns.
Panitchob, N, Li, L, Huang, J, Ranjan, R, Ideker, RE, Dosdall, DJ (2017). Endocardial Activation Drives Activation Patterns During Long-Duration Ventricular Fibrillation and Defibrillation. Circ Arrhythm Electrophysiol, 10, 12:no page given.