Past Presentations
Resolving Cellular Senescence Heterogeneity with Single-Cell and Spatial Transcriptomics
In this video segment of the CVRTI Seminar Series, invited speaker, Dr. Neretti, PhD, discusses: Resolving Cellular Senescence Heterogeneity with Single-Cell and Spatial Transcriptomics
Speaker:
Nicola Neretti, PhD
Associate Professor of Biology Associate Director of the Center on the Biology of Aging Brown University
Principles of Action Potential Conduction in Cardiac Tissue
In this video segment of the CVRTI Seminar Series, invited speaker, Dr. Rudy, PhD, discusses: Principles of Action Potential Conduction in Cardiac Tissue
Speaker:
Yoram Rudy, PhD
Distinguished Professor Emeritus Washington University in Saint Louis Member, US National Academy of Engineering Fellow, US National Academy of Inventors
Visualizing Autonomic Control of Cardiac Electrophysiology
In this video segment of the CVRTI Seminar Series, invited speaker, Dr. Ripplinger, PhD, discusses: Visualizing Autonomic Control of Cardiac Electrophysiology
Speaker:
Crystal M Ripplinger, PhD, FHRS, FAHA
Professor and Vice Chair for Research and Administration Department of Pharmacology University of California Davis School of Medicine
A Tale of Two Potassium Channels
In this video segment of the CVRTI Seminar Series, invited speaker, Dr. Sanguinetti, PhD, discusses: A Tale of Two Potassium Channels
Speaker:
Michael Sanguinetti, PhD
Professor Emeritus, Department of Internal Medicine University of Utah
Interleukin Signaling in Cardiac Repair and Regeneration
In this video segment of the CVRTI Seminar Series, invited speaker, Dr. Meara, PhD, discusses :Interleukin Signaling in Cardiac Repair and Regeneration
Speaker:
Caitlin O’Meara, PhD
Associate Professor of Physiology
Cardiovascular CenterGenomics Sciences and Precision Medicine CenterMedical College of Wisconsin
Structural Basis for Cation-Chloride Cotransporter Inhibition by Diuretic Drugs and Activation by Kinases
In this video segment of the CVRTI Seminar Series, invited speaker, Dr. Cao, PhD, discusses :Structural Basis for Cation-Chloride Cotransporter Inhibition by Diuretic Drugs and Activation by Kinases
Speaker:
Erhu Cao, PhD
Associate Professor Department of Biochemistry University of Utah School of Medicine
Leveraging Big Data and Unique Cohorts to Understand the Basis of Diabetes and Diabetic Complications
In this video segment of the CVRTI Seminar Series, invited speaker, Dr. Pezzolesi, PhD, discusses :Leveraging Big Data and Unique Cohorts to Understand the Basis of Diabetes and Diabetic Complications
Speaker:
Marcus G. Pezzolesi, PhD, MPH
Associate Professor, Department of Internal Medicine, Division of Nephrology and Hypertension Adjunct, Department of Human Genetics Department of Nutrition and Integrative Physiology Diabetes and Metabolism Center, University of Utah
Effects of Autonomic Nervous System Activity on Arrhythmias
In this video segment of the CVRTI Seminar Series, invited speaker, Dr. Shelton, MD, discusses :Effects of Autonomic Nervous System Activity on Arrhythmias
Speaker:
Richard Shelton MD, MSc, Assistant Professor of Clinical Medicine Salt Lake City, VA Health Care System University of Utah Director of the Autonomic Dysfunction Clinic for the Division of Cardiology
Novel noncoding RNA drugs for cardiac fibrosis and inflammation
In this video segment of the CVRTI Seminar Series, invited speaker, Dr. Marban, PhD, discusses :Novel noncoding RNA drugs for cardiac fibrosis and inflammation
Speaker:
Eduardo Marbán, MD, PhD Mark S. Siegel Family Foundation Distinguished Professor Executive Director, Smidt Heart Institute Cedars-Sinai Medical Center
Getting to the Heart of the Matter: Myosin Modulation in Heart Failure
In this video segment of the CVRTI Seminar Series, invited speaker, Dr. Malik, PhD, discusses : Getting to the Heart of the Matter: Myosin Modulation in Heart Failure
Speaker:
Fady I. Malik, MD, PhD Executive Vice President, Research and Development, Cytokinetics Clinical Professor of Medicine, UCSF
Faster Drug Trials using Al, ‘Omics, and many single-subject studies
In this video segment of the CVRTI Seminar Series, invited speaker, Dr. Lussier, MD, discusses :
Faster Drug Trials using Al, ‘Omics, and many single-subject studies
Speaker:
Yves Lussier, MD, FACMI Professor and Chair of Biomedical Infomatics School of Medicine University of Utah
Neurocirculatory Control Mechanisms: consequences of 02 supply in health and disease
In this video segment of the CVRTI Seminar Series, invited speaker, Dr. Amann, PhD, discusses : Neurocirculatory Control Mechanisms: consequences of 02 supply in health and disease
Speaker:
Yves Lussier, MD, FACMI Professor and Chair of Biomedical Infomatics School of Medicine University of Utah
Role of the Ventricular Conduction System in Arrythmias and Antiarrhythmic Therapy
In this video segment of the CVRTI Seminar Series, invited speaker, Dr. Dosdall, PhD, discusses : Role of the Ventricular Conduction System in Arrythmias and Antiarrhythmic Therapy
Speaker:
Derek J. Dosdall, PhD. Associate Professor of Surgery, Division of Cardiothoracic Surgery. Associate Director, Nora Eccles Harrison CVRTI. The University of Utah
Redefining Sudden Cardiac Death : Insights from the POST SCD Study
In this video segment of the CVRTI Seminar Series, invited speaker, Dr. Tseng, M.D., discusses :Redefining Sudden Cardiac Death : Insights from the POST SCD Study
Speaker:
Zian H. Tseng.M.D., MA.S.. F.HRS Professor of Medicine in ResidenceMurray Davis Endowed ProfessorCardiac Electrophysiology Section, Cardiology DivisionUniversity of California, San Francisco
Understanding underlying mechanisms to inform future therapeutic strategies
In this video segment of the CVRTI Seminar Series, invited speaker, Dr. Zachary Stephen Clayton, PhD, discusses :Accelerated vascular aging induced by common chemotherapeutic agents: Understanding underlying mechanisms to inform future therapeutic strategies
Speaker:
Zachary Stephen Clayton, PhD Assistant Research Professor Assistant Laboratory Director, Integrative Physiology of Aging Laboratory, Department of Integrative Physiology University of Colorado Boulder
During an Immune Response, Force Awakens the Light and Dark Sides of T cells
In this video segment of the CVRTI Seminar Series, invited speaker, Dr. Brian Evavold, PhD, discusses :During an Immune Response, Force Awakens the Light and Dark Sides of T cells
Speaker:
Brian Evavold,PhD George J. Weber Presidential Endowed Chair in Immunology, Professor,Chief , Division of Microbiology and Immunology, ViceChair for Research Department of Pathology, University of Utah
Traffic Control of the Slow Delayed Rectifier Channel in Adult Ventricular Myocytes
In this video segment of the CVRTI Seminar Series, invited speaker, Dr. Gea-Ny Tseng, PhD, discusses :Traffic Control of the Slow Delayed Rectifier Channel in Adult Ventricular Myocytes
Speaker:
Gea-Ny Tseng, PhD, Professor, School of Medicine Physiology and Biophysics, Virginia Commonwealth University
Mechanisms of Hypoglycemia-Induced Cardiac Arrhythmias in Type 1 Diabetes
In this video segment of the CVRTI Seminar Series, invited distinguished speaker, Dr. Candace Reno, PhD, discusses : Mechanisms of Hypoglycemia-Induced Cardiac Arrhythmias in Type 1 Diabetes
Speaker:
Candace Reno, PhD, Research Assistant Professor of Internal Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Utah
New Therapies for Hypertrophic Cardiomyopathy: Some things old and some things new
In this video segment of the CVRTI Seminar Series, invited distinguished speaker, Dr. Sharlene M. Day, MD, discusses : New Therapies for Hypertrophic Cardiomyopathy: Some things old and some things new
Speaker:
Sharlene M. Day, MD, Associate Professor of Medicine and Genetics, Director of Translational Research for Cardiovascular Medicine and Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania
Novel risk stratification approaches in electrophysiology
In this video segment of the CVRTI Seminar Series, invited distinguished speaker, Dr. Benjamin A. Steinberg, MD, discusses : Novel risk stratification approaches in electrophysiology
Speaker:
Benjamin A. Steinberg, MD, MHS, FACC, FHRS, Associate Professor of Medicine, Cardiovascular Medicine Division, University of Utah
Cardio-Oncology: A Novel Platform forCardiovascular Investigation
In this video segment of the CVRTI Seminar Series, invited distinguished speaker, Dr. Javid Moslehi, MD, discusses Cardio-Oncology: A Novel Platform for Cardiovascular Investigation.
Speaker:
Javid Moslehi, MD, William Grossman Distinguished Professor in Cardiology, Section Chief, Cardio-Oncology & Immunology, Associate Professor in Residence, UCSF School of Medicine, Cardiovascular Research Institute (CVRTI), University of California San Francisco
The secret life of the endothelium
In this video segment of the CVRTI Seminar Series, invited distinguished speaker, Dr. Lisa A. Lesniewsk, discusses the secret life of the endothelium.
Speaker:
Lisa A. Lesniewski, MA, PhD, Professor of Internal Medicine, Division of Geriatrics, Adjunct Associate Professor, Department of Nutrition and Integrative Physiology, GRECC Investigator and Co-Principal Investigator of the Translational Vascular Physiology Lab
How to Improve Brain Health in Patients with Atrial Fibrillation
In this video segment of the CVRTI Seminar Series, invited distinguished speaker, Dr. Jared Bunch, discusses improving brain health in patients with atrial fibrillation.
Speaker:
T. Jared Bunch, MD Professor of Medicine Section Chief, Clinical Cardiac Electrophysiology University of Utah
Cardiac Sarcomere Protein Quality Control and BAG3: Repairing the Engine without Stopping the Car
In this video segment of the CVRTI Seminar Series, invited speaker, Dr. Jonathan Kirk, discusses cardiac sarcomere protein quality control and the gene encoding BAG3.
Dr. Kirk discusses the challenges involved with repairing the sarcomere without stopping the heart, analogous to repairing a car engine without stopping the car. His work builds on prior studies from the late 1960s that examine how heart muscle becomes weak in heart failure. Currently, Dr. Kirk explores the role of BAG3 and other associated proteins in the failing heart.
Speaker:
Jonathan A. Kirk, PhD.
Associate Professor
Department of Cell and Molecular Physiology
Loyola University Chicago Stritch School of Medicine
Cardiac MRI for Measuring Myocardial Fibrosis, Perfusionand Oxygenation
In this video segment of the CVRTI Seminar Series, invited speaker, Dr. Edward Dibella, discusses Cardiac MRI imaging for measuring myocardial fibrosis, perfusion and oxygenation.
Dr. Dibella discusses the technical mechanism and physics involved with generating an MRI image and the relevance of imaging in the cardiology clinical setting. The seminar concludes with a discussion on the challenges of obtaining images and future directions for improving MRI imaging to obtain better results in the cardiovascular system.
Speaker:
Edward Dibella, PhD. Professor of Radiology and Imaging Sciences Adjunct Professor of Electrical & Computer Engineering and Biomedical Engineering Director of the Utah Center for Advanced Imaging Research (UCAIR) University of Utah, Salt Lake City, Utah
Myocarditis: From Coxsackies Virus to Cytoskeleton to COVID-19
In this video segment of the CVRTI Seminar Series, invited distinguished speaker, Dr. Kirk Knowlton, presents his current research on myocarditis involving the cytoskeletal elements found in heart muscle cells in response to exposure to viruses such as Coxsackievirus and Coronavirus.
Dr. Knowlton begins the seminar with a look at traditional myocarditis. The Knowlton Lab investigates possible genetic and/or environmental factors which compromise the cell membrane and allow a virus to enter the cell much easier than under normal conditions. Dr. Knowlton concludes with a discussion of COVID-19 effects on the cardiovascular system and possible treatment approaches, including a discussion on monoclonal antibody treatment of COVID-19 as it pertains to the heart.
Speaker:
Kirk U. Knowlton, M.D., FACC, FAHA Intermountain Medical Center Salt Lake City, Utah
Arterial Senescence and Telomere Dysfunction: Implications for Arterial Aging
In this video segment of the CVRTI Seminar Series, invited distinguished University of Utah speaker, Dr. Anthony Donato, describes arterial senescence (cell death) and telomere dysfunction relating to arterial aging.
Dr. Donato’s findings suggest the majority of cardiovascular death is due to arterial disease. His laboratory investigates the capped ends of chromosomes, also known as telomeres, and uses translational research genetic models to explore possible interventions to preserve telomere length and arterial health.
Speaker:
Anthony Donato, PhD. Co-Directory, Translation Vascular Physiology Laboratory Professor, Department of Internal Medicine, University of Utah
Exercise and Plakophilin-2 Deficiency: The Double-Hit of Arrhythmogenic Cardiomyopathy
In this video segment of the CVRTI Seminar Series, invited distinguished speaker, Dr. Mario Delmar, describes the function and role of the gene Plakophilin-2 (PKP2) in Arrhythmogenic Right Ventricular Cardiomyopathy—an inherited heart muscle disease.
Dr. Delmar’s findings suggest that a mutation in the PKP2 gene can cause the muscle cells of the heart to be replaced with fatty tissue causing the normally strong but flexible heart, to be more rigid and weak. This disease may at first be quite subtle with effects such as diminished performance, but can advance to more serious effects including heart failure and sudden cardiac death.
Speaker:
Mario Delmar, MD, PhD Patricia M. and Robert H. Martinsen Professor of Cardiology, Department of Medicine at NYU Grossman School of Medicine Professor, Department of Cell Biology at NYU Grossman School of Medicine New York University
Modeling and Imaging Cardiac Electrical Excitation
In this video segment of the CVRTI Seminar Series, invited distinguished speaker, Dr. Yoram Rudy, presents his current research of modeling and imaging cardiac electrical excitation.
Dr. Rudy’s discussion of his current work follows disease progression starting with ion channels located inside the cells of the heart, where structural changes cause electrical activity of the heart to change. These changes often have a dramatic impact on the larger components causing deleterious effects in larger systems such as cells, tissues, organs and even the entire organism. Dr. Rudy developed Non-Invasive Electrocardiographic Imaging (ECGI) to aid in the detection and treatment of these cardiovascular anomalies.
Speaker:
Yoram Rudy Ph.D., F.A.H.A., F.H.R.S Director, Cardiac Bioelectricity and Arrhythmia Center (CBAC) The Fred Saigh Distinguished Professor of Engineering Professor of Biomedical Engineering, Cell Biology & Physiology, Medicine, Radiology, and Pediatrics Washington University, St. Louis, Missouri
