RESEARCH PUBLICATIONS OF 2021

• Lange M, Hirahara AM, Ranjan R, Stoddard GJ, Dosdall DJ (2021). Atrial slow conduction develops and dynamically expands during premature stimulation in an animal model of persistent atrial fibrillation. PLoS One, 16(10), e0258285.
• Frank B Sachse, Robert W Hitchcock, Nassir F Marrouche, Nathan J Knighton, Chao Huang. Devices, systems, and methods for imaging and treating a selected tissue. US Patent 11,154,186. 2021
• Carley AN, Maurya SK, Fasano M, Wang Y, Selzman CH, Drakos SG, Lewandowski ED. Short Chain Fatty Acids Outpace Ketone Oxidation in the Failing Heart. Circulation. 2021 Feb 19.
• Maron BA, Wang RS, Shevtsov S, Drakos SG, Arons E, Wever-Pinzon O, Huggins GS, Samokhin AO, Oldham WM, Aguib Y, Yacoub MH, Rowin EJ, Maron BJ, Maron MS, Loscalzo J. Individualized interactomes for network-based precision medicine in hypertrophic cardiomyopathy with implications for other clinical pathophenotypes. Nat Commun. 2021 Feb 8;12(1):873.
• Thirupura S Shankar, Dinesh Kumar Anandamurugan Ramadurai, Kira Steinhorst, Salah Sommakia, Rachit Badolia, ASPASIA SPYRIDOULA THODOU KROKIDI, Dallen Calder, Sutip Navankasattusas, Jing Ling, Ohyun Kwon, Emily Cheng, Russel Richardson, Frank B Sachse, Johann Schredelseker, Kenneth Spitzer, Dipayan Chaudhuri, Stavros G Drakos. Abstract P467: Cardiac-specific Deletion Of Voltage Dependent Anion Channel 2 Leads To Dilated Cardiomyopathy By Altering Calcium Homeostasis. Circulation Research 129 (Suppl_1), AP467-AP467c
• Michio Sato, Tsuyoshi Kadomatsu, Keishi Miyata, Junco Wddcarren, Zhe Tian, Shunshun Zhu, Haruki Horiguchi, Aman Makaju, Anna Bakhtina, Jun Morinaga, Taichi Sugizaki, Kaname Hirashima, Kumiko Yoshinobu, Mai Imasaka, Masatake Araki, Yoshihiro Komohara, Tomohiko Wakayama, Shinichi Nakagawa, Sarah Franklin, Koichi Node, Kimi Araki, and Yuichi Oike. The lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis.  Nature Communications (accepted)
• João Salinet, Rubén Molero, Fernando Soares Schlindwein, Joël Karel, Miguel Rodrigo, José Luis Rojo-Álvarez, Omer Berenfeld, Andreu Climent, Brian Zenger, Frederique Jos Vanheusden, Jimena Gabriela Siles Paredes, Rob MacLeod, Felipe Atienza, María S Guillem, Matthijs Cluitmans, Pietro Bonizzi. “Electrocardiographic imaging for atrial fibrillation: a perspective from computer models and animal experiments to clinical value “ Frontiers in Physiology (EP) (accepted)
• DS Li, EA Mendiola, R Avazmohammadi, FB Sachse, MS Sacks. A Large-scale 3D Micromechanical Computational Myocardium Mode. 2021
• Khan, Muhammad S., Shaw, Robin M. “Huntington’s disease skeletal muscle has altered T-tubules” JGP Journal of General Physiology, Online Issn: 1540-7748, Print Issn: 0022-1295, 12 May 2021
• Good WW, Zenger B, Bergquist JA, Rupp LC, Gillette K, Angel N, Chou D, Plank G, MacLeod RS. JCombining endocardial mapping and electrocardiographic imaging (ECGI) for improving PVC localization: A feasibility study.ournal of electrocardiology 2021 ;
• Good WW, Gillette KK, Zenger B, Bergquist JA, Rupp LC, Tate J, Anderson D, Gsell MAF, Plank G, MacLeod RS。Estimation and Validation of Cardiac Conduction Velocity and Wavefront Reconstruction Using Epicardial and Volumetric Data.IEEE transactions on bio-medical engineering 2021 ; 68 11 : 3290-3300
• Shaw RM, “Ion Channel Trafficking in the Heart” CARDIAC ELECTROPHYSIOLOGY: From Cell to Bedside, 8/E., 2021, ed. Zipes DP, Jalife J.
• Pacheco C, Wei J, Shufelt C, Hitzeman TC, Cook-Wiens G, Pepine CJ, Handberg E, Anderson RD, Petersen JW, Hong T, Shaw RM, Bairey Merz CN. Association of coronary microvascular dysfunction and cardiac bridge integrator 1, a cardiomyocyte dysfunction biomarker. Clin Cardiol 2021 (in press)
• Nathan J. Knighton, Brian K. Cottle, Sarthak Tiwari, Abhijit Mondal, Aditya K. Kaza, Frank B. Sachse, Robert W. Hitchcock. Toward cardiac tissue characterization using machine learning and light-scattering spectroscopy. J. of Biomedical Optics, 26(11), 116001 (2021).
• Delisle BP, Aromolaran AS. (2021). Editorial: Perturbations in Metabolic Cues: Implications for Adverse Cardiac Function Leading to Sudden Cardiac Death. Front Physiol. 12, doi: 10.3389/fphys.2021.788904. PMID: 34867488; PMCID: PMC8634259 
• Aromolaran AS (2021). Is there an emerging role for IKs in aging-related ventricular arrhythmias? J Cell Physiol. Dec 8. doi: 10.1002/jcp.30658. 
• DeAngelo MM, Peacock JB, Holeman TA, Maloney M, Beckstrom J, Brooke BS. Long-Term Functional Decline Following Vascular Surgery Among Vulnerable Adults. Ann Vasc Surg. 2021 Oct;76:87-94. doi: 10.1016/j.avsg.2021.04.002. Epub 2021 Apr 22. PubMed PMID: 33895257; PubMed Central PMCID: PMC8531166.
• Healy AH, Bowen M, McKellar SH, Koliopoulou A, Drakos SG, Selzman CH (2021). Interleukin-1 Receptor Antagonism as Adjunct Therapy for Heart Failure Patients with Left Ventricular Assist Devices. ASAIO J, 67(8), e145-e147.
• David R Eberhardt, Sandra H Lee, Xue Yin, Anthony M Balynas, Emma Rekate, Jackie N Kraiss, Marisa J Lang, Maureen A Walsh, Molly E Streiff, Andrea C Corbin, Katsuhiko Funai, Frank B Sachse, Dipayan Chaudhuri. EFHD1 ablation reduces cardiac mitoflash activation and protects cardiomyocytes from ischemia. bioRxiv. 2021
• Chowdhury KH, Martinez-Mateu L, Do J, Aromolaran KA, Saiz J, Aromolaran AS (2021). Macrophage-Dependent Interleukin-6-Production and Inhibition of I_KContributes to Acquired QT Prolongation in Lipotoxic Guinea Pig Heart. Int J Mol Sci, 22(20).
• Javan H, Li L, Schaaf CL, Lee YS, Salama ME, Dinarello CA, Selzman CH (2021). Interleukin 1 receptor antagonism abrogates acute pressure-overload induced murine heart failure. Ann Thorac Surg.
• Diakos NA, Taleb I, Kyriakopoulos CP, Shah KS, Javan H, Richins TJ, Yin MY, Yen CG, Dranow E, Bonios MJ, Alharethi R, Koliopoulou AG, Taleb M, Fang JC, Selzman CH, Stellos K, Drakos SG (2021). Circulating and Myocardial Cytokines Predict Cardiac Structural and Functional Improvement in Patients With Heart Failure Undergoing Mechanical Circulatory Support. J Am Heart Assoc, 10(20), e020238.
• Aparna C Sankarankutty, Joachim Greiner, Jean Bragard, Joseph R Visker, Thirupura S Shankar, Christos P Kyriakopoulos, Stavros G Drakos, Frank B Sachse. Etiology-Specific Remodeling in Ventricular Tissue of Heart Failure Patients and Its Implications for Computational Modeling of Electrical Conduction. Frontiers in physiology 12. 2021
• Shimura D, Nuebel E, Baum R, Valdez SE, Xiao S, Warren JS, Palatinus JA, Hong T, Rutter J, Shaw RM. Protective mitochondrial fission induced by stress-responsive protein GJA1-20k. Elife. 2021 Oct 5;10. doi: 10.7554/eLife.69207. PubMed PMID: 34608863; PubMed Central PMCID: PMC8492060.
• Selzman CH, Drakos SG, Chaudhuri D. FGF21 (Fibroblast Growth Factor 21) Defines a Potential Cardiohepatic Signaling Circuit in End-Stage Heart Failure. Circ Heart Fail. 2021 Dec 6;:CIRCHEARTFAILURE121008910. doi: 10.1161/CIRCHEARTFAILURE.121.008910. [Epub ahead of print] PubMed PMID: 34865514; NIHMSID:NIHMS1756360.
• Khan MS, Lange M, Ranjan R, Sharma V, Glotzbach JP, Selzman C, Dosdall DJ (2021). Premature atrial stimulation accentuates conduction abnormalities in cardiac surgery patients that develop postoperative atrial fibrillation. J Electrocardiol, 69, 36-43.
• Shaw RM, Saffitz JE (2021). A role for connexin-43 in Duchenne muscular dystrophy cardiomyopathy. J Clin Invest, 130(4), 1608-1610.
• NJ Knighton, BK Cottle, BEB Kelson, RW Hitchcock, FB Sachse. Towards intraoperative quantification of atrial fibrosis using light-scattering spectroscopy and convolutional neural networks. Sensors 21 (18), 6033. 2021
• Kamali R, Kump J, Ghafoori E, Lange M, Hu N, Bunch TJ, Dosdall DJ, Macleod RS, Ranjan R (2021). Area Available for Atrial Fibrillation to Propagate Is an Important Determinant of Recurrence After Ablation. JACC Clin Electrophysiol, 7(7), 896-908.
• Hunt B, Kwan E, McMillan M, Dosdall D, MacLeod R, Ranjan R (2021). Deep Learning Based Prediction of Atrial Fibrillation Disease Progression with Endocardial Electrograms in a Canine Model. Comput Cardiol, 47.
• Shanmugam G, Wang D, Gounder SS, Fernandes J, Litovsky SH, Whitehead K, Radhakrishnan RK, Franklin S, Hoidal JR, Kensler TW, DellItalia L, Darley-Usmar V, Abel ED, Jones DP, Ping P, Rajasekaran NS (2021). Reductive Stress Causes Pathological Cardiac Remodeling and Diastolic Dysfunction. Antioxid Redox Signal, 32(18), 1293-1312.
• Hunt B, Kwan E, McMillan M, Dosdall D, MacLeod R, Ranjan R (2021). Deep Learning Based Prediction of Atrial Fibrillation Disease Progression with Endocardial Electrograms in a Canine Model. Comput Cardiol, 47.
• T. S. Shankar, D. K. A. Ramadurai, K. Steinhorst, S. Sommakia, R. Badolia, A. T. Krokidi, D. Calder, S. Navankasattusas, P. Sander, O. S. Kwon, A. Aravamudhan, J. Ling, A. Dendorfer, C. Xie, O. Kwon, E. Cheng, K. Whitehead, T. Gudermann, R. Richardson, F. B. Sachse, J. Schredelseker, K. Spitzer, D. Chaudhuri, and Stavros Drakos. Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis. Nat Comm, 7(1):1-11, 2021. Published, 07/2021.
• D. S. Li, E. A. Mendiola, R. Avazmohammadi, F. B. Sachse, and M. S. Sacks. A high-fidelity 3d micromechanical model of ventricular myocardium. In D. B. Ennis, L. E. Perotti, and V. Y. Wang, editors, Lecture Notes in Computer Science, 12738, 168-177, 2021. Published, 07/01/2021.
• Y. Lyu, V. K. Verma, Y. Lee, I. Taleb, R. Badolia, T. S. Shankar, C. P. Kyriakopoulos, C. H. Selzman, W. Caine, R. Alharethi, S. Navankasattusas, T. Seidel, S. G. Drakos, and F. B. Sachse. Remodeling of t-system and proteins underlying excitation-contraction coupling in aging versus failing human heart. NPJ Aging and Mechanisms of Disease, 7(1):1-11, 2021. Published, 06/01/2021.
• Selzman CH, Tonna JE, Pierce J, Vargas C, Skidmore C, Lewis G, Hatton ND, Phillips JD (2021). A pilot trial of human amniotic fluid for the treatment of COVID-19. BMC Res Notes, 14(1), 32.
• Hydren JR, Gifford JR, Jarrett CL, Park SH, Shields KL, Broxterman RM, Kithas AC, Bisconti AV, Thurston TS, Ratchford SM, Wray DW, Stehlik J, Selzman CH, Drakos SG, Richardson RS (2021). Vascular Function in Continuous-Flow Left Ventricular Assist Device Recipients: Effect of a Single Pulsatility Treatment Session. (Epub ahead of print) Am J Physiol Regul Integr Comp Physiol.
• Hoffman M, Palioura D, Kyriazis ID, Cimini M, Badolia R, Rajan S, Gao E, Nikolaidis N, Schulze PC, Goldberg IJ, Kishore R, Yang VW, Bannister TD, Bialkowska AB, Selzman CH, Drakos SG, Drosatos K (2021). Cardiomyocyte Krüppel-like Factor 5 Promotes De Novo Ceramide Biosynthesis and Contributes to Eccentric Remodeling in Ischemic Cardiomyopathy. (Epub ahead of print) Circulation.
• Healy AH, Bowen M, McKellar SH, Koliopoulou A, Drakos SG, Selzman CH (2021). Interleukin-1 Receptor Antagonism as Adjunct Therapy for Heart Failure Patients with Left Ventricular Assist Devices. (Epub ahead of print) ASAIO J.
• Musfee FI, Agopian AJ, Goldmuntz E, Hakonarson H, Morrow BE, Taylor DM, Tristani-Firouzi M, Watkins WS, Yandell M, Mitchell LE (2021). Common Variation in Cytoskeletal Genes is Associated with Conotruncal Heart Defects. Genes (Basel), 12(5).
• Gakenheimer-Smith L, Meyers L, Lundahl D, Menon SC, Bunch TJ, Sawyer BL, Tristani-Firouzi M, Etheridge SP (2021). Expanding the phenotype of CACNA1C mutation disorders. Mol Genet Genomic Med, e1673.
• Bernardi J, Aromolaran KA, Zhu H, Aromolaran AS (2021). Circadian Mechanisms: Cardiac Ion Channel Remodeling and Arrhythmias. Front Physiol, 11, 611860.
• Shankar TS, Ramadurai DKA, Steinhorst K, Sommakia S, Badolia R, Thodou Krokidi A, Calder D, Navankasattusas S, Sander P, Kwon OS, Aravamudhan A, Ling J, Dendorfer A, Xie C, Kwon O, Cheng EHY, Whitehead KJ, Gudermann T, Richardson RS, Sachse FB, Schredelseker J, Spitzer KW, Chaudhuri D, Drakos SG. Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis. Nat Commun. 2021 Jul 28;12(1):4583. 
• Kamali R, Kump J, Ghafoori E, Lange M, Hu N, Bunch TJ, Dosdall DJ, Macleod RS, Ranjan R. Area Available for Atrial Fibrillation to Propagate Is an Important Determinant of Recurrence After Ablation. JACC. Clinical electrophysiology 2021 ;
• Good WW, Zenger B, Bergquist JA, Rupp LC, Gillette KK, Gsell MAF, Plank G, MacLeod RS. Quantifying the spatiotemporal influence of acute myocardial ischemia on volumetric conduction velocity. Journal of electrocardiology 2021 ; 66 : 86-94
• Bergquist JA, Good WW, Zenger B, Tate JD, Rupp LC, MacLeod RS. The electrocardiographic forward problem: A benchmark study.Computers in biology and medicine 2021 ; 134 : 104476
• Zenger B, Good WW, Bergquist JA, Rupp LC, Perez M, Stoddard GJ, Sharma V, MacLeod RS. Pharmacological and simulated exercise cardiac stress tests produce different ischemic signatures in high-resolution experimental mapping studies. Journal of electrocardiology 2021 ; 68 : 56-64
• Zenger B, Good WW, Bergquist JA, Rupp LC, Perez M, Stoddard GJ, Sharma V, MacLeod RS. Transient recovery of epicardial and torso ST-segment ischemic signals during cardiac stress tests: A possible physiological mechanism. Journal of electrocardiology 2021 ;
• Charlebois CM, Caldwell DJ, Rampersad SM, Janson AP, Ojemann JG, Brooks DH, MacLeod RS, Butson CR, Dorval AD. Validating Patient-Specific Finite Element Models of Direct Electrocortical Stimulation. Frontiers in neuroscience 2021 ; 15 : 691701
• Bergquist JA, Coll-Font J, Zenger B, Rupp LC, Good WW, Brooks DH, MacLeod RS. Simultaneous Multi-Heartbeat ECGI Solution with a Time-Varying Forward Model: a Joint Inverse Formulation.Functional imaging and modeling of the heart : … International Workshop, FIMH …, proceedings. FIMH 2021 ; 12738 : 493-502
• Carley AN, Maurya SK, Fasano M, Wang Y, Selzman CH, Drakos SG, Lewandowski ED (2021). Short-Chain Fatty Acids Outpace Ketone Oxidation in the Failing Heart. Circulation, 143(18), 1797-1808.
• Shah P, Psotka M, Taleb I, Alharethi R, Shams MA, Wever-Pinzon O, Yin M, Latta F, Stehlik J, Fang JC, Diao G, Singh R, Ijaz N, Kyriakopoulos CP, Zhu W, May CW, Cooper LB, Desai SS, Selzman CH, Kfoury AG, Drakos SG (2021). Framework to Classify Reverse Cardiac Remodeling With Mechanical Circulatory Support: The Utah-Inova Stages. Circ Heart Fail, 14(5), e007991.
• Tonna JE, Pierce J, Hatton N, Lewis G, Phillips JD, Messina A, Skidmore CR, Taylor K, Selzman CH (2021). Safety and feasibility of using acellular sterile filtered amniotic fluid as a treatment for patients with COVID-19: protocol for a randomised, double-blinded, placebo-controlled clinical trial. BMJ Open, 11(2), e045162.
• Selzman C (2021). Commentary: Latent hypertrophic obstructive cardiomyopathy-(Un)clear and present danger. J Thorac Cardiovasc Surg.
• Sharma V, Glotzbach JP, Ryan J, Selzman CH (2021). Evaluating Quality in Adult Cardiac Surgery. Tex Heart Inst J, 48(1).