Nora Eccles Harrison Cardiovascular Research & Training Institute

Imaging Techniques for Early Detection of Atherosclerosis

human brain and heart

What is Atherosclerosis and Its Relation to Heart Disease?

Atherosclerosis is the process of arterial plaque buildup that narrows the arteries, blocking blood flow to the heart, brain, arms, legs, and kidneys. The accumulation comes from cholesterol, saturated fats, and calcium deposits, and severe blockages can lead to blood clots or fatal outcomes. This condition can be dangerous, so early detection of atherosclerosis is crucial in stabilization and further prevention.

Imaging Methods for Early Detection of Atherosclerosis

Luckily, there are several methods, like imaging techniques, for early detection of atherosclerosis. 

MRI

High-resolution MRIs, for instance, provide detailed imaging and information about existing plaque formations. It allows healthcare providers to see the composition of arterial plaque buildup, enabling them to devise a plan of action to prevent further buildup.

Angiography

Angiography is another imaging technique for the early detection of atherosclerosis. A special type of X-ray, this method uses contrast dye to receive visuals of arteries throughout the body, particularly the heart, neck, and brain. It helps healthcare professionals see the narrowing (stenosis) of arterial passages.

Cardiac MRIs

Cardiac MRIs are specific to atherosclerosis in the heart. They detect tissue damage or blood flow issues, acting as an invaluable tool for assessing atherosclerosis progression in serious cases. Healthcare professionals also utilize ultrasound machines, fluorescence, and photoacoustic imaging to scan blood vessels. Each imaging method works in different ways to detect high-risk atherosclerosis early.

The Best Imaging Modality for Atherosclerosis

MRIs, also known as high-resolution magnetic resonance imaging, have become a popular method of atherosclerosis detection and risk assessment. Unlike other arterial visualization and examination methods, MRIs provide high-resolution pictures without ionizing radiation. When combined with angiography, they are a safe, reliable technique for studying vessel walls and surrounding arterial plaque buildup. In some cases, healthcare providers may measure blood flow and stenosis damage after an MRI with an ultrasound.

While MRIs are most common and considered the best imaging modality for atherosclerosis, each imaging technique has its strengths. Used in sequence, each imaging system provides a closer look and detailed understanding of arterial plaque buildup and associated health risks.

Detecting Atherosclerosis Early 

Atherosclerosis can be difficult to pinpoint because it progresses silently, often remaining elusive until symptoms become severe. However, attention to how you feel and regular healthcare checkups can lead to earlier detection.

Some Signs of Intravascular Arterial Plaque Buildup Include

  • Chest pain or intense tightness or pressure. It becomes severe with physical activity, then subsides with rest, but the pattern is consistent.
  • Extreme fatigue or shortness of breath.
  • Difficulty speaking or weakness and loss of control on one side of the body. These are called transient ischemic attacks, often occurring before a stroke caused by an arterial blockage.
  • Poor circulation in the legs and calf muscle pain while walking.
  • Poor wound healing.
  • Reduced pulses in the feet.

If you experience these symptoms, a healthcare professional can use risk assessment and testing to check blood sugar and cholesterol levels. High levels increase the risks of atherosclerosis, which may lead to further testing to evaluate arterial inflammation and heart function.

What Is the Diagnostic Imaging of Atherosclerosis?

Diagnostic imaging of atherosclerosis varies, but common methods include:

  • Heart scans (coronary calcium scans) use a CT scan to detect calcium deposits that may hinder blood flow in the heart’s arteries.
  • Doppler sonograms arean ultrasound technique that measures the velocity and direction of blood flow to assess arterial blockages.
  • Thallium and myocardial perfusion scans track blood flow through the heart muscle during rest and intense exercise.

These diagnostic imaging systems utilize different techniques to detect abnormalities in blood flow because atherosclerosis involves narrowing arteries, which obstructs blood flow. With timely intervention, healthcare professionals can develop a plan for better management of atherosclerosis.

ypes of Imaging Used to Identify Atherosclerosis

Healthcare professionals utilize a combination of imaging methods to detect and identify atherosclerosis. Magnetic resonance angiography (MRA), for instance, is an advanced imaging technique that provides detailed visuals of large arteries. MRAs can reveal severe inflammation, arterial plaque buildup, and metabolic activity to determine how quickly arterial issues could be resolved or better managed.

Cardiac catheterization and angiogram are other imaging techniques that use a flexible tube inserted into a blood vessel and guided to the heart. Used in suspected severe atherosclerosis cases, this method involves contrast dye injected into the catheter, where blood flow guides it through the arteries. It helps determine how severely arteries are narrowed or blocked. With proper identification, healthcare providers can better monitor atherosclerosis progression and prevent further damage.

Frequently Asked Questions

What is the Ankle-Brachial Index (ABI) and why is it important?

ABI compares blood pressure measurements in the ankle and the arm to detect peripheral artery disease (PAD). This simple, quick, and non-invasive test can be performed in your doctor’s office without requiring special preparation. An ABI of less than 0.9 is considered abnormal and suggests potential blockages in leg arteries, which may indicate atherosclerosis elsewhere in the body, such as in the heart or brain arteries.

How is coronary calcium scoring interpreted?

Your calcium score reflects the extent of plaque buildup in your heart’s arteries. A score of zero suggests a very low risk of heart disease, while scores between 1-99 indicate mild plaque buildup. Scores of 100-399 suggest moderate plaque and increased heart disease risk, while scores above 400 indicate extensive plaque and high risk. Higher scores typically lead to further testing and more aggressive treatment approaches for coronary artery disease.

What are the limitations of different imaging techniques?

Each imaging method has distinct advantages and drawbacks. MRI offers detailed images without radiation exposure, but procedures take longer and may not be suitable for patients with certain metal implants like pacemakers or cochlear implants. CT scans provide fast results but involve radiation exposure, which can be concerning with frequent use. Ultrasound is completely safe and non-invasive, but image quality may vary depending on the patient’s body type and the technician’s skill level. Angiography provides the most detailed arterial views but is an invasive procedure with small risks, including bleeding or injury to blood vessels.

How do doctors interpret atherosclerosis imaging results?

Doctors assess the degree of stenosis, or narrowing of the arteries, to determine atherosclerosis severity and guide treatment decisions. Mild stenosis of less than 50% can often be managed effectively with lifestyle changes and medications, while severe stenosis greater than 70% may require procedures like angioplasty with stenting or bypass surgery. These imaging results help doctors assess your risk of heart attack or stroke and determine whether more aggressive interventions are necessary for optimal cardiovascular protection.

Do I need multiple imaging tests?

Many patients require a combination of imaging tests because different techniques provide complementary information. For example, a calcium scan might detect plaque presence, while an ultrasound measures blood flow, and MRI shows plaque composition. Your doctor will typically start with the least invasive tests and progress to more detailed studies if needed, creating a complete picture of your cardiovascular health.