CVRTI Electrophysiology Program

The CVRTI Electrophysiology Program consists of laboratories that explore the formation of electrical activity in the heart, understanding how the electrical system coordinates every heartbeat, the mechanisms of dangerous arrhythmias (which are disturbances of the electrical system), and how the electrical system can be used as a diagnostic for acute cardiac events.

The investigators of the program are Ademuyiwa Aromolaran, PhD (Director), Derek Dosdall, PhD, Rob MacLeod, PhD, and Ravi Ranjan, MD, PhD. The Aromolaran Lab focuses on sudden cardiac death and arrhythmias with a goal of arrhythmia therapy to normalize sinus rhythm and help promote longevity and quality of life in patients. To advance this objective, the Aromolaran Lab utilizes individual or multiple combinations of state-of-the-art approaches (including cellular and clinical electrophysiology, optical imaging, and computer simulations), in both preclinical small and large animal models to address fundamental questions in ion channel biology/electrophysiology and how this relates to acquired arrhythmias with implications for the identification and validation of novel druggable targets. The Dosdall Lab uses different mapping techniques to understand arrhythmia mechanisms and also develop novel therapies for failing hearts. The Ranjan Lab has extensive experience in clinical electrophysiology and advanced models of disease to investigate arrhythmia mechanisms. The MacLeod Lab focuses on the electrocardiographic mapping of the heart and body surface, cardiac electrophysiology, and computational electrophysiology.