End-stage human heart failure induces development of sheet-like invaginations of the cell membrane

Drs. Drakos, Sachse, Selzman, and Tristani-Firouzi demonstrate that end-stage human heart failure induces development of sheet-like invaginations of the cell membrane that may constitute a precondition and predictor for functional cardiac recovery after mechanical unloading. _{T. Seidel, S. Navankasattusas, A. Ahmad, N. A. Diakos, W. D. Xu, M. Tristani-Firouzi, M. J. Bonios, I. Taleb, D. Y. Li, C. H. Selzman, S. G. Drakos, and F. B. Sachse. Sheet-like remodeling of the transverse tubular system in human heart failure impairs excitation-contraction coupling and functional recovery by mechanical unloading. Circ, 135(17):1632-45, 2017.}