Nora Eccles Harrison Cardiovascular Research & Training Institute
CVRTI Team Photo

The TVP Laboratory’s research is focused on the mammalian vascular system. It is the lifeline of all tissues and organs within the body. Stretched end-to-end, the arteries, veins, and other vessels of the human circulatory system would measure about 60,000 miles, and in a given day, the human heart pumps about 1,800 gallons of blood through this vast network. Despite its quite pedestrian appearance, the vasculature is not just a system of static plumbing. It is a dynamic and multifunctional series of tissues. The large arteries serve to dampen the pulse of blood ejected from the heart, while small arteries help to dispense oxygen and nutrients to tissues in metabolic need. Like a fine symphony conductor, when operating properly, advancing age, obesity, and rare genetic mutations lead to a dysfunctional vascular system resulting in peripheral tissue damage and dysfunction. Our laboratory seeks to understand the basic mechanisms behind this dysfunction and explores lifestyle and pharmacological interventions that can restore its normal function in older or obese populations and in patients with rare vascular diseases. We utilize a translational approach to answer these questions utilizing cell culture, animal models, and human arteries.

Human body vein diagram

Featured Publications

The TVP Lab Research Team

 ANTHONY JOHN DONATO

Principal Investigator

LISA LESNIEWSKI

Principal Investigator

VENKATESWARA REDDY GOGULAMUDI

FELLOWS

SAMUEL BLOOM

Ph.D. Student

MD TORIKUL ISLAM

Ph.D. Student

MD TORIKUL ISLAM

RESEARCH ASSISTANTS