Nora Eccles Harrison Cardiovascular Research & Training Institute

The Ranjan Laboratory

The Ranjan lab Cardiovascular Research Team at CVRTI Fall BBQ
Ranjan Laboratory Activation Time Diagram CVRTI

The Ranjan Laboratory’s research is focused on cardiac recovery associated with unloading and mechanical circulatory support (MCS) in the chronic heart failure (HF) setting and the acute setting (i.e. acute HF/cardiogenic shock). We have published original work generated both in the clinical arena and in our laboratory which led to the founding and establishment of the award-winning multidisciplinary Utah Cardiac Recovery Program (UCAR). The research initiatives of UCAR are developed in close connection and alignment to the development of its clinical aspects. This parallel development facilitates a full circle bidirectional synergy which is mutually beneficial to the research and clinical potentials.

Featured Publications

Area Available for Atrial Fibrillation to Propagate Is an Important Determinant of Recurrence After Ablation

https://pubmed.ncbi.nlm.nih.gov/33640348/

This data provides mechanistic insights into AF recurrence, suggesting that post-ablation scar pattern dividing the atria into smaller regions is an important and better predictor than LA volume and total scar, with improved long-term outcomes in persistent AF.

Kamali, R; Kump, J; Ghafoori, E; Lange, M; Hu, N; Bunch, T J; Dosdall, D J; Macleod, R S; Ranjan, R
Area Available for Atrial Fibrillation to Propagate Is an Important Đeterminant of Recurrence After Ablation
JACC Clin Electrophysiol, 2021.

Reproducibility of clinical late gadolinium enhancement magnetic resonance imaging in detecting left atrial scar after atrial fibrillation ablation

https://pubmed.ncbi.nlm.nih.gov/32931635/

Our results demonstrate that clinical LGE-MRI can be reliably used for visualizing PAAS across different magnetic flux densities if the threshold is greater than 70th percentile of the wall intensity distribution. Also, atrial wall-based thresholding is better than BP-based thresholding for reproducible PAAS detection.

Kamali, R, Schroeder, J, DiBella, E, Steinberg, B, Han, F, Dosdall, DJ, Macleod, RS, Ranjan, R (2020). Reproducibility of clinical late gadolinium enhancement magnetic resonance imaging in detecting left atrial scar after atrial fibrillation ablation. J Cardiovasc Electrophysiol, 31, 11:2824-2832.

Reproducibility of clinical late gadolinium enhancement magnetic resonance imaging in detecting left atrial scar after atrial fibrillation ablation

https://pubmed.ncbi.nlm.nih.gov/32931635/

Our results demonstrate that clinical LGE-MRI can be reliably used for visualizing PAAS across different magnetic flux densities if the threshold is greater than 70th percentile of the wall intensity distribution. Also, atrial wall-based thresholding is better than BP-based thresholding for reproducible PAAS detection.

Kamali, R, Schroeder, J, DiBella, E, Steinberg, B, Han, F, Dosdall, DJ, Macleod, RS, Ranjan, R (2020). Reproducibility of clinical late gadolinium enhancement magnetic resonance imaging in detecting left atrial scar after atrial fibrillation ablation. J Cardiovasc Electrophysiol, 31, 11:2824-2832.

The Ranjan Lab Research Team

Ravi Ranjan, M.D., Ph.D