The MacLeod Laboratory
The Computational Electrocardiology Laboratory’s research studies electrocardiographic mapping of the heart and body surface. Specific research areas includes cardiac electrophysiology in the study of acute ischemia and repolarization abnormalities; and computational electrophysiology in solving electrocardiographic forward and inverse problems.
Bioelectric Analyses of an Osseointegrated Intelligent Implant Design System for Amputees
The goal of the osseointegrated intelligent implant design (OIID) system is to make the implant part of an electrical system to accelerate skeletal attachment and help prevent periprosthetic infection. To determine optimal electrode size and placement, we initiated proof of concept with computational modeling of the electric fields and current densities that arise during electrical stimulation of amputee residual limbs.
Bioelectric analyses of an osseointegrated intelligent implant design system for amputees. B.M. Isaacson, J.G. Stinstra, R.S. MacLeod, J.B. Webster, J.P. Beck, and R.D. Bloebaum.
Detection and Quantification of Low Voltage Left Atrial Tissue Using Delayed Enhancement MRI in Patients with Atrial
Atrial fibrillation (AF) is associated with diffuse left atrial fibrosis and a reduction in endocardial voltage.
Detection and Quantification of Low Voltage Left Atrial Tissue Using Delayed Enhancement MRI in Patients with Atrial Fibrillation. R.S. Oakes, T.J. Badger, E.G. Kholmovski, N.M. Segerson, E.V.R. DiBella, E. Fish, JE. Blauer, N. Akoum, M. Daccarett, J. Windfelder, C. J. McGann, D. Parker, R.S. MacLeod, N.F. Marrouche.
Subject-specific, multiscale simulation of electrophysiology: a software pipeline for image based models and application examples.
Interest in image-based modelling is based on the growing access of biomedical
Subject-specific, multiscale simulation of electrophysiology: a software pipeline for image based models and application examples. R.S. MacLeod, J.G. Stinstra, S. Lew, R.T. Whitaker, D.J. Swenson, M.J. Cole, J. Krueger, D.H. Brooks, and C.R. Johnson. Phil. Trans. R. Soc. 367:2293-2310, 2009.