The Hoareau Laboratory

The Hoareau Acute Care and Translational Research Laboratory investigates how mitochondrial injury drives organ dysfunction after trauma, hemorrhagic shock, and ischemia-reperfusion, and how targeted mitochondrial therapies can restore cellular and tissue resilience. The lab’s work is grounded in the concept that mitochondrial dysfunction is not uniform across organs or cell populations. Instead, it occurs in spatially and temporally heterogeneous patterns that shape clinical outcomes. Using a combination of translational large-animal models, small-animal studies, and mechanistic cellular approaches, the laboratory examines mitochondrial energetics, redox balance, structural integrity, and stress signaling in the heart, kidney, and vascular beds. A major focus of the lab is the development and evaluation of mitochondrial-targeted interventions, including peptide-based therapies that preserve mitochondrial architecture and function following severe physiological stress. By integrating clinically realistic models with deep mechanistic readouts, the Hoareau Laboratory aims to define actionable mitochondrial phenotypes that can be translated into novel resuscitation and organ-protective strategies.