Timeline Stories

Category: Timeline Stories

All timeline stories.

Two grids compare heart activity in control and infarcted tissues at 30ms and 200ms. Each grid shows torso, measured, and reconstructed maps, with color gradients representing electrical potentials over time.

2000 ECG Imaging of Electrophysiologically Abnormal Substrates in Infarcted Hearts

Drs. MacLeod and Taccardi strengthen the validity of using electrocardiographic imaging to detect and localize areas of myocardial infarct and structural disease. Burnes JE, Taccardi B, MacLeod RS, and Rudy Y. Noninvasive ECG Imaging of electrophysiologically abnormal substrates in infarcted hearts. A model study. Circulation, 101 (5), 533-540, 2000

A panoramic view of a city set against a backdrop of rugged, sunlit mountains under a blue sky, with buildings and greenery spread across the valley in the foreground.

1999 Co-Directors

Rob MacLeod, PhD, Kenneth Spitzer, PhD, and Bruno Taccardi, MD, PhD are appointed co-Directors.

A set of scientific images: (a) and (b) show cell cultures with stained regions; (c) shows a blot with labeled bands for Bcl-3; (d) shows a time-course blot for Bcl-3 with fold increase values listed below each lane.

1998 Human Platelets Translate Messenger RNAs

Drs. Elstad, McIntyre, Prescott, Weyrich, and Zimmerman demonstrate that activated human platelets translate messenger RNAs, which are basally present in an extensive and diverse endogenous transcriptome, to critical biologically-active proteins, fundamentally altering paradigms in platelet biology. Weyrich AS, Dixon DA, Ravinder P, Elstad MR, McIntyre TM, Prescott SM, Zimmerman GA. Signal-dependent translation of a regulatory … Read more

Thermal images showing heat distribution on human torsos, viewed from the front and back. Three plates compare temperature changes before and after treatments at different times and sites, with color scales indicating heat intensity.

1997 Three-Dimensional Electrical Activation of the Ventricles

Drs. Ershler, Lux, and Taccardi demonstrate electrical recordings from the body surface can reliably detect three-dimensional electrical activation of the ventricles. Oster HS, Taccardi B, Lux RL, Ershler PR, Rudy Y. Noninvasive Electrocardiographic Imaging: Reconstruction of Epicardial Potentials, Electrograms, and Isochrones and Localization of Single and Multiple Electrocardiac Events. Circulation, 96 (3), 1012-1024, 1997

Screenshot of a research article titled A Mechanistic Link Between an Inherited and an Acquired Cardiac Arrhythmia: HERG Encodes the IKr Potassium Channel with the abstract text partially visible below.

1995 LQT

Sanguinetti and Keating publish a mechanistic cause for long QT syndrome (LQT).

Three line graphs show PAF acetylhydrolase levels across fractions for abetalipoproteinemia (A, one peak left), normal (B, two peaks labeled HDL and LDL), and Tangier disease (C, one peak center). Y-axis: enzyme activity; X-axis: fraction number.

1989 First Plasma Lipid

Drs. McIntyre, Prescott, Stafforini, and Zimmerman first demonstrate that the plasma lipid environment significantly modulates PAF hydrolase activity provided the basis for further research concerning lipid signaling and inflammatory regulation. Stafforini DM, Carter ME, Zimmerman GA, McIntyre. TM, Prescott SM. Lipoproteins alter the catalytic behavior of the platelet-activating factor acetylhydrolase in human plasma. PNAS 86, … Read more

Black and white microscopic image showing several round, textured cells clustered together against a darker background. A letter C appears in the top right corner.

1985 Inflammatory Cell-Cell Interactions

Drs. McIntyre, Prescott, and Zimmerman demonstrate that thrombin promotes neutrophil-endothelial interaction provided the basis for further research regarding inflammatory cell-cell interactions. Zimmerman GA, McIntyre TM, Prescott SM. Thrombin stimulates the adherence of neutrophils to human endothelial cells in vitro. J. Clin. Invest. 76, 2235-2246, 1985