2003 Dr. Sheets Defines the Molecular Basis of Lidocaine’s Effect on Sodium Channel Gating

A: Traces showing electrical recordings under control and lidocaine conditions. B & C: Plots with open and filled circles, showing current-voltage relationships for DI-R1C and DII-R1Q, with sigmoidal curves and a horizontal dashed line.

Dr. Sheets defines the molecular basis of lidocaine’s effect on sodium channel gating. Sheets MF and Hanck DA. Molecular action of lidocaine on the voltage sensors of sodium channels. J. Gen. Physiol. 121:163-175, 2003