PUBLICATIONS
Balderas E, Eberhardt DR, Lee S, Pleinis JM, Sommakia S, Balynas AM, Yin X, Parker MC, Maguire CT, Cho S, Szulik MW, Bakhtina A, Bia RD, Friederich MW, Locke TM, Van Hove JLK, Drakos SG, Sancak Y, Martin Tristani-Firouzi M, Franklin S, Rodan AR, Chaudhuri D. (2022) Mitochondrial calcium uniporter stabilization preserves energetic homeostasis during Complex I impairment. Nature Communications. In Press.
Sato M, Kadomatsu T, Miyata K, Warren J, Tian Z, Zhu S, Horiguchi H, Makaju A, Bakhtina A, Morinaga J, Sugizaki T, Hirashima K, Yoshinobu K, Imasaka M, Araki M, Komohara Y, Wakayama T, Nakagawa S, Franklin S, Node K, Araki K, Oike Y. (2021) The lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis. Nature Communications. 5; 12(1):2529. PMID: 33953175.
Hickenlooper SM, Davis K, Szulik MW, Sheikh H, Miller M, Valdez S, Bia R, Franklin S. (2022) Histone H4K20 trimethylation is decreased in murine models of heart disease. ACS Omega. DOI: 10.1021/acsomega.2c00984
Davis K, Azarcon P, Hickenlooper S, Bia R, Horiuchi E, Szulik MW, Franklin S. (2021) The role of demethylases in cardiac development and disease. JMCC. S0022-2828(21) 00112-7. PMID: 34081951
Sato M, Kadomatsu T, Miyata K, Warren J, Tian Z, Zhu S, Horiguchi H, Makaju A, Bakhtina A, Morinaga J, Sugizaki T, Hirashima K, Yoshinobu K, Imasaka M, Araki M, Komohara Y, Wakayama T, Nakagawa S, Franklin S, Node K, Araki K, Oike Y. (2021) The lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis. Nature Communications. 5; 12(1):2529. PMID: 33953175.
Szulik MW, Davis K, Bakhtina A, Azarcon P, Bia R, Horiuchi E, Franklin S. (2020) Transcriptional regulation by methyltransferases and their role in the heart: highlighting novel emerging functionality. AJP-Heart and Circ. Physiol. 319(4):H847-H865. PMID:32822544.
Shanmugam G, Wang D, Gounder SS, Fernandes J, Litovsky SH, Whitehead K, Radhakrishnan RK, Franklin S, Hoidal J, Kensler TW, Dell'Italia L, Darley-Usmar V, Abel ED, Jones DP, Ping P. Namakkal Soorappan R. (2020) Reductive Stress Causes Pathological Cardiac Remodeling and Diastolic Dysfunction. Antioxidants and Redox Signaling. 32(18): 1293-1312. PMID: 32064894
Ludlam WG, Aoba T, Cuéllar J, Bueno-Carrasco MT, Makaju A, Moody JD, Franklin S, Valpuesta JM, Willardson BM. (2019) Molecular architecture of the Bardet-Biedl Syndrome protein core complex. Journal of Biological Chemistry 294(44): 16385-16399. PMID: 31530639.
Buffolo M, Pires KM, Ferhat M, Ilkun O, Makaju A, Achenbach A, Bowman F, Atkinson DL, Holland, WL, Amri E, Chaurasia B, Franklin S, Boudina S. (2019) Identification of a Paracrine Signaling Mechanism Linking CD34high Progenitors to the Regulation of Visceral Fat Expansion and Remodeling. Cell Reports 29(2): 270-282. PMID: 31597091
Buffolo M, Pires KM, Ferhat M, Ilkun O, Makaju A, Achenbach A, Bowman F, Atkinson DL, Holland, WL, Amri E, Chaurasia B, Franklin S, Boudina S. (2019) Identification of a Paracrine Signaling Mechanism Linking CD34high Progenitors to the Regulation of Visceral Fat Expansion and Remodeling. Cell Reports (In Press).
Warren J, Tracy CM, Miller MR, Makaju A, Szulik MW, Yuzyuk TN, Barton DW, Wang L, García J, Sabry AD, Cawley K, Cox J, Yong Hwan Han, Boudina S, Fiehn O, Tucker H, Zaitsev AV, Franklin S. (2018) Histone Methyltransferase Smyd1 Regulates Mitochondrial Energetics in the Heart. PNAS, 115 (33): E7871-E7880. PMID: 30061404.
Tracy C, Warren J, Szulik M, Wang L, Garcia J, Makaju A, Russel K, Miller M, Franklin S. (2017) The Smyd family of methyltransferases: Role in cardiac and skeletal muscle physiology and pathology. Current Opinion in Physiology. 1:140-152.
Miller MR, Franklin S, Foster DB. (2016) Organelle, Protein and Peptide Fractionation in Cardiovascular Proteomics. Chapter In Manual of Cardiovascular Proteomic. Editors: Agnetti, Lindsey and Foster. DOI:10.1007/978-3-319-31828-8.
Franklin S, Kimball T, Rasmussen TL, Rosa-Garrido M, Chen H, Tran T, Miller MR, Gray R, Jiang S, Ren S, Wang Y, Tucker HO, Vondriska TM. (2016)The chromatin binding protein Smyd1 restricts adult mammalian heart growth. AJP-Heart and Circ. Physiol. PMID:27663768. [pdf]
Velinder, M.; Singer, J.; Meznarich, J.; Bareyan, D.; Tracy C. M.; Fulcher, J.; McClellan, D.; Lucente, H.; Franklin, S.; Sharma, S.; Engel, M. E. (2016)Gfi1 functions in transcriptional control and cell fate 1 determination require snag domain methylation to recruit LSD1. Biochem J. 473(19):3355-69. PMID:27480105. [pdf]
Monte E, Rosa-Garrido M, Karbassi E, Chen H, Lopez R, Rau CD, Wang J, Nelson SF, Wu Y, Stefani E, Lusis AJ, Wang Y, Kurdistani SK, Franklin S, Vondriska TM. (2016)Reciprocal Regulation of the Cardiac Epigenome by Chromatin Structural Proteins HMGB and CTCF: Implications for Transcriptional Regulation. J Biol Chem. PMID:27226577. [pdf]
Shimizu H, Schredelseker J, Huang J, Lu K, Naghdi S, Lu F, Franklin S, Fiji HDG, Wang K, Zhu H, Tian C, Lin B, Nakano H, Nakai J, Stieg AZ, Gimzewski JK, Nakano A, Goldhaber JI, Vondriska TM, Hajnóczky G, Kwon O, Chen JN (2015). Mitochondrial Ca2+ uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity. Elife 4. PMID: 25588501. PMID:25588501. [pdf]
Plimpton RL, Cuéllar J, Lai CW, Aoba T, Makaju A, Franklin S, Mathis AD, Prince JT, Carrascosa J, Valpuesta JM, Willardson BM (2015). Structures of the G beta CCT and PhLP1 G beta CCT complexes reveal a molecular mechanism for G protein beta subunit folding and beta gamma dimer assembly. PNAS. 112(8):2413-8. PMID: 25675501. PMID:25675501. [pdf]
Shibayama J, Yuzyuk T, Cox J , Makaju A, Miller M, Lichter J, Li H, Leavy JD, Franklin S, Zaitsev AV (2015). Metabolic Remodeling in Moderate Synchronous versus Dyssynchronous Pacing-Induced Heart Failure: Integrated Metabolomics and Proteomics Study. PLoS One. 10(3):e0118974. PMID: 25790351. PMID:25790351. [pdf]
Kumar PP, Emechebe U, Smith R, Franklin S, Moore B, Yandell M, Lessnick SL, Moon AM (2014). Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex. Elife 3:e02805. PMID: 24876127. PMID:24876127. [pdf]
Puvula P, Franklin S, Emechebe U, Hu H, Moore B, Lehman C, Yandell M, Moon A (2014). TBX3 regulates splicing in vivo: a novel molecular mechanism for ulnar-mammary syndrome. PLoS Genet. 10(3):e1004247. PMID:24675841. [pdf]
Monte E, Mouillesseaux K, Chen H, Ren S, Wang Y, Chen JN, Vondriska TM, Franklin S (2013). Systems proteomics of cardiac chromatin identifies Nucleolin as a regulator of growth and cellular plasticity in cardiomyocytes. AJP-Heart and Circ. Physiol. 305(11): H1624-38. PMID:24077883. [pdf]
Lu G, Ota A, Ren S, Franklin S, Rau CD, Ping P, Lane TF, Zhou H, Reue K, Lusis AJ, Vondriska TM, Wang Y (2013). PPM1l encodes an inositol requiring-protein 1 (IRE1) specific phosphatase that regulates the functional outcome of the ER stress response. Molecular Metabolism 2(4):405-416. PMID:24327956. [pdf]
Chen H, Monte E, Vondriska TM, Franklin S. Systems proteomics of healthy and diseased chromatin. Chapter In Heart Proteomics: methods and protocols. Editor: F. Vivanco. Methods Mol. Biol. 2013. 1005:77-93. PMID:23606250. [pdf]
Monte E, Chen H, Kolmakova M, Parvatiyar MS, Vondriska TM, Franklin S. Quantitative analysis of chromatin proteomes in disease. J. Vis Exp. 2012. doi:pii: 4294. 10.3791. PMID: 23299252. [pdf]
Chen H, Monte E, Parvatiyar MS, Rosa-Garrido M, Franklin S, Vondriska TM. Structural considerations for chromatin state models with transcription as a functional readout. FEBS Lett. 2012. 586(20) 3548-54. PMID: 22940112. [pdf]
Mitchell-Jordan S, Chen H, Franklin S, Stefani E, Bentolila LA, Vondriska TM. Features of endogenous cardiomyocyte chromatin revealed by super-resolution STED microscopy. J Mol Cell Cardiol. 2012. 53(4) 552-8. PMID: 22846883. [pdf]
Franklin S*, Chen H, Mitchell-Jordan SA, Ren S, Wang Y, Vondriska TM*. Quantitative analysis of the chromatin proteome in disease reveals remodeling principles and identifies high mobility group protein B2 as a regulator of hypertrophic growth. Mol Cell Proteomics. 2012. 11(6):M111.014258. PMID:22270000. *Denotes co-corresponding authorship. [pdf]
Franklin S*, Vondriska TM*. Genomes, proteomes, and the central dogma. Circulation Cardiovasc Genet. 2011; 4(5):576. Invited Review. PMID:22010165. [pdf]
Javaherian AD, Yusifov T, Pantazis A, Franklin S, Gandhi CS, Olcese R. Metal-driven operation of the human large-conductance voltage- and Ca2+-dependent potassium channel (BK) gating ring apparatus. J. Biol. Chem. 2011; 286(23) 20701-9. PMID:21471215. [pdf]
Li Y, Franklin S, Zhang M, Vondriska TM. Highly efficient purification of protein complexes from mammalian cells using a novel streptavidin-binding peptide and hexahistidine tandem tag system: application to Bruton’s tyrosine kinase. Protein Science. 2011; 20(1) 140-9. PMID:21080425. [pdf]
Franklin S*, Zhang M, Chen H, Paulsson AK, Mitchell-Jordan SA, Li Y, Ping P, Vondriska TM*. Specialized compartments of cardiac nuclei exhibit distinct proteome anatomy. Mol Cell Proteomics. 2010; 10(1).PMID:20807835. *Denotes co-corresponding authorship. [pdf]
Zhang MJ, Franklin S, Li Y, Wang S, Ru X, Mitchell-Jordan S, Mano H, Stefani E, Ping P, Vondriska TM. Stress signaling by Tec tyrosine kinase in ischemic myocardium. Am J Physiol Heart Circ Physiol. 2010; 299(3) H713-22. PMID:20543088. [pdf]
Paulsson AK*, Franklin S*, Mitchell-Jordan SA, Ren S, Wang Y, Vondriska TM. Post-translational regulation of calsarcin-1 during pressure overload induced cardiac hypertrophy. J Mol Cell Cardiol. 2010; 48(6) 1206-14. PMID:20170660. *Denotes equal contribution. [pdf]
Lomenick B, Hao R, Jonai N, Chin RM, Aghajan M, Warburton S, Wang J, Wu RP, Gomez F, Loo JA, Wohlschlegel JA, Vondriska TM, Pelletier J, Herschman HR, Clardy J, Clarke CF, Huang J. Target identification using drug affinity responsive target stability (DARTS). Proc Natl Acad Sci. 2009; 106(51) 21984-9. PMID:19995983. [pdf]
Singh H, Warburton S, Vondriska TM, Khakh BS. Proteomics to identify proteins interacting with P2X2 ligand-gated cation channels. J Vis Exp. 2009; 18(27): 1178. PMID:19455095. [pdf]
Lu G, Sun H, She P, Youn JY, Warburton S, Ping P, Vondriska TM, Cai H, Lynch CJ, Wang Y. Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells. J Clin Invest. 2009; 119(6): 1678-87. PMID:19411760. [pdf]
Mitchell-Jordan SA, Holopainen T, Ren S, Wang S, Warburton S, Zhang MJ, Alitalo K, Wang Y, Vondriska TM. Loss of Bmx non-receptor tyrosine kinase prevents pressure overload-induced cardiac hypertrophy. Circ Res. 2008; 103(12): 1359-62. PMID:18988895. [pdf]
Warburton S, White MY, Van Eyk JE, Cotter RJ, Ping P, Dunn MJ, Vondriska TM. Cardiovascular Initiative of the Human Proteome Organisation, 5th Workshop October 2007, Seoul, Korea. Proteomics 2008; 8(5): 924-926. PMID:18240139. [pdf]
Warburton S, Davis WE, Southwick K, Xin H, Woolley AT, Burton GF, Thulin CD. Proteomic and phototoxic characterization of melanolipofuscin: Correlation to disease and model for its origin. Molecular Vision 2007; 13:318-329. PMID:17392682. [pdf]
Warburton S, Southwick K, Hardman RM, Secrest AM, Grow RK, Xin H, Woolley AT, Burton GF, Thulin CD. Examining the proteins of functional retinal lipofuscin using proteomic analysis as a guide for understanding its origin. Molecular Vision 2005; 11:1122-34. PMID:16379024. [pdf]
