The Sachse Labratory
Intraoperative identification and avoidance of the CCS is thus a key strategy to improve surgical outcomes. In order to avoid conduction tissue damage and mitigate morbidity a number of approaches have been developed. Here, we review the historical and contemporary approaches for identification of conduction tissue during cardiac surgery
Sachse, FB, Johnson, J, Cottle, B, Mondal, A, Hitchcock, R, Kaza, AK (2020). Heart Rhythm, 17, 12:2200-2207.
Our review stressed the potential of catheterized optical tools to improve diagnosis and treatment of patients with heart disease.
Huang, C, Knighton, N, Timmins, LH, Sachse, FB. Progress in Biomedical Engineering. 2, 032001
Transient receptor potential canonical 1 (TRPC1) protein is abundantly expressed in cardiomyocytes. While TRPC1 is supposed to be critically involved in cardiac hypertrophy, its physiological role in cardiomyocytes is poorly understood. We investigated the subcellular location of TRPC1 and its contribution to Ca2+ signaling in mammalian ventricular myocytes.
Hu, Q, Ahmad, AA, Seidel, T, Hunter, C, Streiff, M, Nikolova, L, Spitzer, KW, Sachse, FB (2020). J Mol Cell Cardiol, 139:113-123.