Nora Eccles Harrison Cardiovascular Research & Training Institute

Timeline Stories

Dr. Sanguinetti describes the molecular basis of gating in a key potassium channel

14 May 2020
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Dr. Sanguinetti describes the molecular basis of gating in a key potassium channel involved in cardiac action potential repolarization.
Wu W, Gardner A, Sanguinetti MC. Cooperative Subunit Interactions Mediate Fast C-type Inactivation of hERG1 K+ Channels. Journal of Physiology. 592(20):4465-4480, 2014.

First intracellular and extracellular pH on calcium handling in heart cells

14 May 2020
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The first comprehensive evaluation of selective actions of intracellular and extracellular pH on calcium handling in heart cells by Dr. Spitzer.
Saegusa, N., Moorhouse, E., Vaughan-Jones, R.D., Spitzer KW. Influence of pH on Ca2+current and its control of electrical and Ca2+ signaling in ventricular myocytes. J Gen Physiol, 138(5), 537-559, 2011.

Dr. Sheets defines the molecular basis of lidocaine’s effect on sodium channel gating

14 May 2020
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Dr. Sheets defines the molecular basis of lidocaine’s effect on sodium channel gating.
Sheets MF and Hanck DA. Molecular action of lidocaine on the voltage sensors of sodium channels. J. Gen. Physiol. 121:163-175, 2003

Dr. Tristani identifies several novel potassium channel mutations

14 May 2020
u0711090
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Dr. Tristani identifies several novel potassium channel mutations that provide new insight concerning the mechanism of cardiac arrhythmia in patients with Anderson syndrome.
Tristani-Firouzi M, Jensen JL, Donaldson MR, Sansone V, Meola G, Hahn A, Bendahhou S, Kwiecinski H, Fidzianska A, Plaster N, Fu YH, Ptacek LJ, Tawil R. Functional and clinical characterization of KCNJ2 mutations associated with LQT7 (Andersen syndrome). J Clin Invest. 110(3):381-388, 2002